{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:25:28Z","timestamp":1773282328059,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,12,10]],"date-time":"2003-12-10T00:00:00Z","timestamp":1071014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>The <jats:italic>GLC1C<\/jats:italic> locus for primary open\u2010angle glaucoma (POAG) is inherited as an autosomal dominant trait. This region on chromosome 3 is 11\u2003cM long. DNA samples from members of a Greek and an American <jats:italic>GLC1C<\/jats:italic> family were obtained to determine whether additional typing of microsatellite markers in family members might narrow the region. <jats:italic>GLC1C<\/jats:italic> family members were evaluated clinically for POAG on the basis of open angles, intraocular pressures, cupping of discs, and visual fields. DNA samples from the Greek and Oregon <jats:italic>GLC1C<\/jats:italic> families were used to further refine the <jats:italic>GLC1C<\/jats:italic> region using microsatellite markers. A total of 22 affected members were identified in the two families. Common alleles for D3S3637 and D3S3612 were present in the disease haplotype from both families, suggesting that they may have a common founder. A newly diagnosed patient in the American family had a recombination in the distal portion of the <jats:italic>GLC1C<\/jats:italic> haplotype. This recombination narrows the <jats:italic>GLC1C<\/jats:italic> region from 11 to 4\u2003cM.<\/jats:p>","DOI":"10.1111\/j..2004.00182.x","type":"journal-article","created":{"date-parts":[[2003,12,10]],"date-time":"2003-12-10T11:45:35Z","timestamp":1071056735000},"page":"40-44","source":"Crossref","is-referenced-by-count":9,"title":["Refining the primary open\u2010angle glaucoma <i>GLC1C<\/i> region on chromosome 3 by haplotype analysis"],"prefix":"10.1111","volume":"65","author":[{"given":"JR","family":"Samples","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Kitsos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Economou\u2010Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Steinkamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Sykes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Rust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Patzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Grigoriadou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Aperis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Psilas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MB","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MK","family":"Wirtz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,12,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.302.6783.998"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304153281507"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1987.01060080068030"},{"key":"e_1_2_6_5_2","first-page":"296","article-title":"Mapping a gene for adult\u2010onset primary open\u2010angle glaucoma to chromosome 3q","volume":"60","author":"Wirtz MK","year":"1997","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200645"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.2.237"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5300.668"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1066901"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0593-47"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00073-7"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/301767"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0434"},{"key":"e_1_2_6_14_2","first-page":"62","article-title":"Mapping of a gene for autosomal dominant juvenile\u2010onset open\u2010angle glaucoma to chromosome 1q","volume":"54","author":"Richards JE","year":"1994","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5287.540"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/302011"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj..2004.00182.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j..2004.00182.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T10:54:23Z","timestamp":1697194463000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j..2004.00182.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,10]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1111\/j..2004.00182.x"],"URL":"https:\/\/doi.org\/10.1111\/j..2004.00182.x","archive":["Portico"],"relation":{},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,10]]}}}