{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:04:32Z","timestamp":1769007872775,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,4,21]],"date-time":"2004-04-21T00:00:00Z","timestamp":1082505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> In paediatric patients, crystalloid prime for cardiopulmonary bypass (CPB) causes further haemodilution in comparison with blood\u2010containing prime. Thus it may affect the cerebral oxygen supply\/demand balance. The purpose of the study was to compare the effect of bloodless pump prime with that of blood\u2010containing prime on cerebral oxygenation in children.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Thirty\u2010six paediatric patients scheduled for elective repair of atrial or ventricular septal defect were enrolled. In Group C (n\u2003=\u200318), the CPB circuit was primed only with crystalloid. In Group B (n\u2003=\u200318), red blood cells were added to achieve a haematocrit (Hct) of 20% during CPB. The regional cerebral oxygen saturation (rSO<jats:sub>2<\/jats:sub>) value measured by near\u2010infrared spectroscopy was compared between the two groups.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In both groups, rSO<jats:sub>2<\/jats:sub> decreased below baseline at the start of CPB and during rewarming (<jats:italic>P\u2003&lt;\u2003<\/jats:italic>0.001, for both groups during each period). At the start of CPB, haemodilution was greater in Group C than in Group B (Hct 16.1\u2003\u00b1\u20030.7% vs. 20.7\u2003\u00b1\u20030.5%; <jats:italic>P\u2003&lt;\u2003<\/jats:italic>0.01), and there was a greater reduction in rSO<jats:sub>2<\/jats:sub> in Group C (49.0\u2003\u00b1\u20035.4% vs. 59.2\u2003\u00b1\u20037.0%; <jats:italic>P\u2003&lt;\u2003<\/jats:italic>0.01). During rewarming, rSO<jats:sub>2<\/jats:sub> was significantly lower in Group C than in Group B (57.8\u2003\u00b1\u20035.3% vs. 62.8\u2003\u00b1\u20036.2%; <jats:italic>P\u2003&lt;\u2003<\/jats:italic>0.01).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> In paediatric patients, the haemodilution associated with crystalloid priming causes a greater reduction in rSO<jats:sub>2<\/jats:sub> than with blood\u2010containing prime at the starting period of CPB and the rewarming period.<\/jats:p>","DOI":"10.1111\/j.0001-5172.2004.00374.x","type":"journal-article","created":{"date-parts":[[2004,4,21]],"date-time":"2004-04-21T15:00:09Z","timestamp":1082559609000},"page":"648-652","source":"Crossref","is-referenced-by-count":20,"title":["The effect of bloodless pump prime on cerebral oxygenation in paediatric patients"],"prefix":"10.1111","volume":"48","author":[{"given":"S. H.","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. S.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. D.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Bahk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. S.","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,4,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951100001724"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03534-8"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03012304"},{"issue":"6","key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/S0022-5223(19)38700-8","article-title":"Cardiac operation for congenital heart disease in children of Jehovah's Witnesses","volume":"89","author":"Henling CE","year":"1985","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02238525"},{"issue":"3","key":"e_1_2_6_7_2","first-page":"I30","article-title":"Total bloodless open heart surgery in the pediatric age group","volume":"70","author":"Kawaguchi A","year":"1984","journal-title":"Circulation"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)00120-9"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/026765919400900403"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1975.tb05842.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199511000-00004"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-0770(99)90005-8"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2003.02788_7.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(98)00024-4"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200106000-00010"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/82.3.418"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199101000-00020"},{"key":"e_1_2_6_18_2","first-page":"633","volume-title":"Cardiopulmonary Bypass","author":"Jaggers JSI","year":"2000"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199205000-00002"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(92)91445-F"},{"issue":"3","key":"e_1_2_6_21_2","first-page":"376","article-title":"The effects of hemodilution on cerebral hemodynamics and oxygen consumption during nonpulsatile hypothermic cardiopulmonary bypass","volume":"42","author":"Endoh H","year":"1993","journal-title":"Masui"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70020-X"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2002.02826.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.93.2.0351"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/73.4.503"},{"issue":"2","key":"e_1_2_6_26_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/01616412.1995.11740293","article-title":"Noninvasive cerebral optical spectroscopy: depth\u2010resolved measurements of cerebral haemodynamics using indocyanine green","volume":"17","author":"Hongo K","year":"1995","journal-title":"Neurol Res"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0001-5172.2004.00374.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0001-5172.2004.00374.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T13:00:58Z","timestamp":1697202058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0001-5172.2004.00374.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,21]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1111\/j.0001-5172.2004.00374.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0001-5172.2004.00374.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,21]]}}}