{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:20:02Z","timestamp":1770430802728,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,5,20]],"date-time":"2004-05-20T00:00:00Z","timestamp":1085011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> To give prophylactics or timely treatment for post\u2010operative nausea and vomiting (PONV) is the question. We compared the intensity and number of disturbing post\u2010operative symptoms (i.e. pain, PONV, headache, fatigue, etc.) after prophylactic antiemetic treatment in a group of patients with &gt;30% risk for post\u2010operative vomiting.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Four hundred and ninety\u2010five patients, from three hospitals, planned for gynaecological surgery were randomized double blind. They were given granisetron 3\u2003mg, droperidol 1.25\u2003mg or no prophylactic antiemetic. Post\u2010operative symptoms were followed for 24\u2003h using a questionnaire. Symptoms were analyzed both according to their intensity and in a dichotomous fashion.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The intensity of different symptoms differed depending on whether droperidol, granisetron or no antiemetic had been given (<jats:italic>P\u2003=<\/jats:italic>\u20030.005) but the overall incidence of moderate to very severe symptoms was similar in all groups. No group fared better in general<jats:italic>.<\/jats:italic> The total number of symptoms was higher in the groups given prophylactic treatment (<jats:italic>P\u2003&lt;<\/jats:italic>\u20030.05). The relative risk reduction for PONV with granisetron or droperidol prophylaxis was 27%[95% confidence interval (CI) 8\u201343] and 22% (2\u201338), respectively. The NNT (number needed to treat) for granisetron (0\u201324\u2003h) was 7 and for droperidol 8. The NNH (number needed to harm) (0\u201324\u2003h) for headache and visual disturbances was 6 and 13 (NS) for granisteron and, 50 (NS) and 6 for droperidol.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The intensity of symptoms or the total number of disturbing symptoms did not decrease after prophylactic antiemetic treatment in a group of patients, but the profile of disturbing symptoms changed. The relevance of post\u2010operative symptoms in terms of patients' well\u2010being needs to be addressed.<\/jats:p>","DOI":"10.1111\/j.0001-5172.2004.00403.x","type":"journal-article","created":{"date-parts":[[2004,6,11]],"date-time":"2004-06-11T15:51:24Z","timestamp":1086969084000},"page":"761-771","source":"Crossref","is-referenced-by-count":23,"title":["Disturbing post\u2010operative symptoms are not reduced by prophylactic antiemetic treatment in patients at high risk of post\u2010operative nausea and vomiting"],"prefix":"10.1111","volume":"48","author":[{"given":"A.","family":"Alkaissi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Gunnarsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Johnsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Evertsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ofenbartl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kalman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,20]]},"reference":[{"key":"e_1_2_32_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/71.4.517"},{"key":"e_1_2_32_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199712000-00001"},{"key":"e_1_2_32_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199902000-00003"},{"key":"e_1_2_32_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199902000-00006"},{"key":"e_1_2_32_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7087.1088"},{"key":"e_1_2_32_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200004000-00007"},{"key":"e_1_2_32_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199906000-00002"},{"key":"e_1_2_32_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200059020-00005"},{"key":"e_1_2_32_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1997.117-az0113.x"},{"key":"e_1_2_32_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1998.tb05157.x"},{"key":"e_1_2_32_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199909000-00022"},{"key":"e_1_2_32_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1998.tb05156.x"},{"key":"e_1_2_32_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03020521"},{"key":"e_1_2_32_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2000.440422.x"},{"key":"e_1_2_32_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03011838"},{"key":"e_1_2_32_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2001.21522"},{"key":"e_1_2_32_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199811000-00020"},{"key":"e_1_2_32_19_2","first-page":"200","article-title":"Y. 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