{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:12:58Z","timestamp":1774923178600,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,2,19]],"date-time":"2004-02-19T00:00:00Z","timestamp":1077148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:p><jats:bold>Background:\u2003<\/jats:bold> Preliminary clinical studies have suggested that gabapentin may produce analgesia and reduce the need for opioids in postoperative patients. The aim of the present study was to investigate the opioid\u2010sparing and analgesic effects of gabapentin administered during the first 24\u2003h after abdominal hysterectomy.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> In a randomized, double\u2010blind study, 80 patients received oral gabapentin 1200\u2003mg or placebo 1\u2003h before surgery, followed by oral gabapentin 600\u2003mg or placebo 8, 16 and 24\u2003h after the initial dose. Patients received patient\u2010controlled analgesia with morphine at doses of 2.5\u2003mg with a lock\u2010out time of 10\u2003min for 24\u2003h postoperatively. Pain was assessed on a visual analogue scale (VAS) at rest and during mobilization, nausea, somnolence and dizziness on a four\u2010point verbal scale, and vomiting as present\/not present at 2, 4, 22 and 24\u2003h postoperatively.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Thirty\u2010nine patients in the gabapentin group, and 32 patients in the placebo group completed the study. Gabapentin reduced total morphine consumption from median 63 (interquartile range 53\u201388) mg to 43 (28\u201360) mg (<jats:italic>P\u2003&lt;\u2003<\/jats:italic>0.001). We observed a significant inverse association between plasma levels of gabapentin at 2\u2003h postoperatively, and morphine usage from 0 to 2\u2003h, and from 0 to 4\u2003h postoperatively (<jats:italic>R<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup>\u2003=\u20030.30, <jats:italic>P\u2003=\u2003<\/jats:italic>0.003 and <jats:italic>R<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup>\u2003=\u20030.24 <jats:italic>P\u2003=\u2003<\/jats:italic>0.008, respectively).<\/jats:p><jats:p>No significant differences in pain at rest or during mobilization, or in side\u2010effects, were observed between groups.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Gabapentin in a total dose of 3000\u2003mg, administered before and during the first 24\u2003h after abdominal hysterectomy, reduced morphine consumption with 32%, without significant effects on pain scores. No significant differences in side\u2010effects were observed between study\u2010groups.<\/jats:p>","DOI":"10.1111\/j.0001-5172.2004.0329.x","type":"journal-article","created":{"date-parts":[[2004,2,19]],"date-time":"2004-02-19T14:36:28Z","timestamp":1077201388000},"page":"322-327","source":"Crossref","is-referenced-by-count":146,"title":["Effects of gabapentin on postoperative morphine consumption and pain after abdominal hysterectomy: A randomized, double\u2010blind trial"],"prefix":"10.1111","volume":"48","author":[{"given":"G.","family":"Dierking","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. H.","family":"Duedahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Fomsgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"M\u00d8iniche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"R\u00d8msing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(97)00084-3"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200209000-00004"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)03313-9"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200209000-00007"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-91-8-437"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199506000-00007"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.21.1837"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.21.1831"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00407-9"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200210000-00036"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/00115550-200107000-00008","article-title":"Effects of gabapentin in acute inflammatory pain in humans","volume":"26","author":"Werner MU","year":"2001","journal-title":"Reg Anesth Pain Med"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200207000-00015"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0001-5172.2004.0329.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0001-5172.2004.0329.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T11:18:37Z","timestamp":1697455117000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0001-5172.2004.0329.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2,19]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["10.1111\/j.0001-5172.2004.0329.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0001-5172.2004.0329.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2,19]]}}}