{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T22:13:48Z","timestamp":1778105628777,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,8,17]],"date-time":"2004-08-17T00:00:00Z","timestamp":1092700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p><jats:bold>Background.\u2002<\/jats:bold> Dystocia\u2014prolonged and difficult labor\u2014is a common and worldwide problem during parturition. Epidemiological studies have suggested a familial aggregation. This study aimed to quantify the genetic influence (i.e. the heritability) on dystocia.<\/jats:p><jats:p><jats:bold>Methods.\u2002<\/jats:bold> A retrospective study of all births in Sweden from 1973 through 1997 was undertaken. Data from the population\u2010based Swedish Birth, Twin and National Family Registers were linked on an individual basis. In total, 2\u2003539\u2003534 births were analyzed. Relationships between sibling and mother\u2013daughter pairs were established. The relative risk for dystocia was calculated. Model\u2010fitting (Mx) was used to estimate the relative contribution of genetic and environmental factors for liability to dystocia.<\/jats:p><jats:p><jats:bold>Results.\u2002<\/jats:bold> In all, 190\u2003747 women were diagnosed with dystocia. Measures of familial similarity (relative risks and correlation of liability) for dystocia were higher in monozygotic than in dizygotic twins, other sibling pairs and mother\u2013daughter pairs. Correlation of liability was also higher in full\u2010sisters than in half\u2010sisters. Model\u2010fitting suggested that genetic effects accounted for 28%[95%\u2003confidence interval (CI) 21\u201332] of the susceptibility for dystocia.<\/jats:p><jats:p><jats:bold>Conclusion.\u2002<\/jats:bold> Dystocia is a complex disorder of poor uterine action that is influenced by a significant genetic component as well as environmental factors. The amount of genetic influence makes it interesting to study the gene expression in these patients. Detection of the genes related to dystocia might lead to better pathophysiological understanding of this condition and the possibility of detecting these mothers before parturition.<\/jats:p>","DOI":"10.1111\/j.0001-6349.2004.00544.x","type":"journal-article","created":{"date-parts":[[2004,8,17]],"date-time":"2004-08-17T16:09:11Z","timestamp":1092758951000},"page":"832-837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Genetic influence on dystocia"],"prefix":"10.1111","volume":"83","author":[{"given":"Michael","family":"Algovik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Cnattingius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Lichtenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agneta","family":"Nordenskj\u00f6ld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Westgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,17]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70080-X"},{"key":"e_1_2_7_3_2","first-page":"486","article-title":"Maternal and neonatal outcomes after prolonged latent phase","volume":"81","author":"Chelmow D","year":"1993","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb13753.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199709000-00005"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5326.681"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.10.4.380"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.10.2451"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1990.tb02569.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb13234.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70260-1"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(96)00064-6"},{"key":"e_1_2_7_13_2","first-page":":5","volume-title":"The Multi\u2010Generation Register","year":"2001"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/140349489001800209"},{"key":"e_1_2_7_15_2","first-page":"3668","article-title":"[Health care registries a community asset. 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