{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:23:51Z","timestamp":1782476631277,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,28]],"date-time":"2004-10-28T00:00:00Z","timestamp":1098921600000},"content-version":"vor","delay-in-days":941,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:sec><jats:title>ABSTRACT<\/jats:title><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objectives of this study were to investigate the prevalence of factor V Leiden mutation in Malay women with recurrent spontaneous abortion and to clarify the contribution of the factor V Leiden mutation to recurrent miscarriages in these women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A prospective case control study between June 1999 and April 2000.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Hospital University Science of Malaysia, Kubang Kerian, Kelantan, and Maternal and Child Health Clinic, Pasir Mas, Kelantan, Malaysia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Samples<\/jats:title><jats:p>A total of 46 Malay women with a history of three or more first or second trimester miscarriages were studied. The control group consisted of 46 parous women without obstetric complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Diagnosis of factor V Leiden mutation was made by examination of factor V Leiden allele product following <jats:italic>Mnl<\/jats:italic> I digestion of factor V Leiden alleles amplified by polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the 46 women with recurrent spontaneous abortion carried the mutation. Also, we found no subject carrying the factor V Leiden alleles in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that that there is no association between the factor V Leiden mutation and recurrent spontaneous abortion in the Malay population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.0004-8666.2002.00164.x","type":"journal-article","created":{"date-parts":[[2004,10,28]],"date-time":"2004-10-28T18:38:31Z","timestamp":1098988711000},"page":"164-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The absence of factor V Leiden mutation in Malays with recurrent spontaneous abortions"],"prefix":"10.1111","volume":"42","author":[{"given":"Narazah Mohd","family":"Yusoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan 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