{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:00:37Z","timestamp":1761487237047},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,28]],"date-time":"2004-10-28T00:00:00Z","timestamp":1098921600000},"content-version":"vor","delay-in-days":758,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:sec><jats:title>ABSTRACT<\/jats:title><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the incidence of and factors affecting risk factors for neonatal group B streptococcal (GBS) sepsis and their predictive values for intrapartum GBS carriage; to calculate the proportions of women eligible for intrapartum antibiotic prophylaxis (IAP) using different selection protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Antenatal clinics and labour wards of a community hospital and a tertiary referral centre in western Sydney.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women attending antenatal clinics during the study periods were invited to participate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Approximately 500 women attending antenatal clinics were screened for GBS carriage at 26\u201332 weeks gestation and at delivery, using several screening methods. Clinical risk factors for neonatal sepsis were recorded during labour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Incidence of antenatal anovaginal GBS carriage and clinical risk factors during labour, their predictive values for intra\u2010partum GBS carriage and their relationship, if any, to demographic and obstetric factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Antenatal and intra\u2010partum GBS carriage rates were similar but varied from 18% to 27%, depending on screening methods. The best positive and negative predictive values of antenatal GBS culture, for intra\u2010partum carriage, were 69% (95% confidence interval (CI) 64\u201374) and 92% (95% CI 50\u201394) respectively. Clinical risk factors occurred in similar proportions of GBS carriers and non\u2010carriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neither early antenatal screening nor clinical risk factors are reliable predictors of intra\u2010partum GBS carriage. Intra\u2010partum antibiotic prophylaxis based on GBS carriage or risk factors when carrier status is unknown would involve \u223c35% of women, compared with \u223c16% if based on risk factors only. Both strategies would prevent similar proportions of neonatal deaths from GBS sepsis. 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