{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:44Z","timestamp":1787014364242,"version":"build-2736575974"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T00:00:00Z","timestamp":1085356800000},"content-version":"vor","delay-in-days":1270,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biometrics"],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p>\n                    <jats:bold>Summary.<\/jats:bold>\n                    Delay until conception is generally described by a mixture of geometric distributions. Weinberg and Gladen (1986,\n                    <jats:italic>Biometrics<\/jats:italic>\n                    <jats:bold>42<\/jats:bold>\n                    , 547\u2013560) proposed a regression generalization of the beta\u2010geometric mixture model where covariates effects were expressed in terms of contrasts of marginal hazards. Scheike and Jensen (1997,\n                    <jats:italic>Biometrics<\/jats:italic>\n                    <jats:bold>53<\/jats:bold>\n                    , 318\u2013329) developed a frailty model for discrete event times data based on discrete\u2010time analogues of Hougaard's results (1984,\n                    <jats:italic>Biometrika<\/jats:italic>\n                    <jats:bold>71<\/jats:bold>\n                    , 75\u201383). This paper is on a generalization to a three\u2010parameter family distribution and an extension to multivariate cases. The model allows the introduction of explanatory variables, including time\u2010dependent variables at the subject\u2010specific level, together with a choice from a flexible family of random effect distributions. This makes it possible, in the context of medically assisted conception, to include data sources with multiple pregnancies (or attempts at pregnancy) per couple.\n                  <\/jats:p>","DOI":"10.1111\/j.0006-341x.2000.01023.x","type":"journal-article","created":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T10:44:09Z","timestamp":1085395449000},"page":"1023-1029","source":"Crossref","is-referenced-by-count":20,"title":["Multivariate Parametric Random Effect Regression Models for Fecundability Studies"],"prefix":"10.1093","volume":"56","author":[{"given":"Ren\u00e9","family":"Ecochard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Clayton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,5,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780071105"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1001\/jama.1985.03350440057031","article-title":"Cigarette smoking associated with delayed conception","volume":"253","author":"Baird D. 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