{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:42:38Z","timestamp":1791103358642,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,7,21]],"date-time":"2004-07-21T00:00:00Z","timestamp":1090368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p><jats:bold>Summary:\u2002<\/jats:bold>  <jats:italic>Purpose:<\/jats:italic> Sudden unexpected death in epilepsy (SUDEP) is a significant health problem for some with epilepsy, but no preventive therapy has been developed for high\u2010risk patients. Sudden death in mice, after sound\u2010induced (audiogenic) seizures, can model the seizure\u2010associated respiratory arrest that contributes to SUDEP in some humans and may be useful for evaluating potential SUDEP therapies. This study evaluated the effects of oxygenation on sudden fatal audiogenic seizures (AGSs) in three mouse strains, DBA\/2J (D2), B6SAS, and primed C57BL\/6J (B6) that differ in genetic background and seizure etiology (idiopathic or acquired).<\/jats:p><jats:p> <jats:italic>Methods:<\/jats:italic> The incidence of fatal AGSs was measured in (a) a normal air environment; (b), an oxygen\u2010rich environment; (c) a normal air environment 24 h after a nonfatal AGS; (d) an oxygen\u2010rich environment 24 h after a nonfatal AGS; and (e) a normal air environment 60 s after exposure to an oxygen\u2010rich environment.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> Sudden, fatal AGS occurred in 100%, 100%, and 58% of the D2, B6SAS, and primed\u2010B6 mice, respectively, in the air environment. Oxygenation completely prevented fatal AGSs in each strain, but had no effect on seizure incidence or severity. Furthermore, the protective effect of oxygenation against fatal seizures occurred only when the mice were in an oxygen\u2010rich environment.<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> These findings indicate that oxygenation prevents sudden death in seizure\u2010prone mice and suggest that oxygenation may protect some seizure\u2010prone humans at risk for SUDEP.<\/jats:p>","DOI":"10.1111\/j.0013-9580.2004.02304.x","type":"journal-article","created":{"date-parts":[[2004,7,21]],"date-time":"2004-07-21T07:15:15Z","timestamp":1090394115000},"page":"993-996","source":"Crossref","is-referenced-by-count":100,"title":["Oxygenation Prevents Sudden Death in Seizure\u2010prone Mice"],"prefix":"10.1111","volume":"45","author":[{"given":"Elizabeth L.","family":"Venit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blythe D.","family":"Shepard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas 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models of multifactorial epilepsies: the EL mouse and mice susceptible to audiogenic seizures","volume":"79","author":"Seyfried TN","year":"1999","journal-title":"Adv Neurol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90294-9"},{"key":"e_1_2_6_16_2","first-page":"97","volume-title":"The Mouse in Biomedical Research","author":"Seyfried TN","year":"1982"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/00223980.1951.9916086"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/genetics\/94.3.701","article-title":"Genetic analysis of audiogenic seizure susceptibility in C57BL\/6J X DBA\/2J recombinant inbred strains of mice","volume":"94","author":"Seyfried 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