{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:01:34Z","timestamp":1695877294505},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,10,27]],"date-time":"2004-10-27T00:00:00Z","timestamp":1098835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p><jats:bold>Summary:\u2002<\/jats:bold>  <jats:italic>Purpose:\u2002<\/jats:italic>To test the validity of a hypothesis that kindling\u2010induced enduring kindling inhibition of the homotopic secondary site is not a primate species\u2010specific effect but occurs also in feline species.<\/jats:p><jats:p> <jats:italic>Methods:\u2002<\/jats:italic>Five mature male cats were kindled at the anterior (AC) and posterior (PC) cingulate cortex followed by secondary\u2010site kindling and primary\u2010site retest.<\/jats:p><jats:p> <jats:italic>Results:\u2002<\/jats:italic>Kindling was characterized by a marked seizure\u2010stage instability and a progressive afterdischarge threshold elevation in all the animals. A protracted nonconvulsive seizure stage was followed by convulsive evolution and rapid generalization. At the secondary site, positive transfer effect was absent, and kindling did not occur. Primary\u2010site retest activated kindled seizure within three stimulations. Recurrent spontaneous seizures, identical to the primary\u2010site kindled seizure, occurred in two AC\u2010kindled animals. Subsequent to this, a markedly elevated afterdischarge threshold also was found at some distant cortical and subcortical sites, to which the afterdischarge propagated. Kindling of the amygdala ipsilateral to the kindled AC or PC was tardy, with no positive transfer effect. However, it was associated with afterdischage threshold reduction.<\/jats:p><jats:p> <jats:italic>Conclusions:\u2002<\/jats:italic>Cingulate kindling\u2010induced enduring kindling inhibition at a homotopic secondary site is not a primate species\u2010specific effect and occurs also in feline species. It is not limited to a homotopic site and represents a lasting secondary antiepileptogenesis, presumably due to enhanced intrinsic inhibitory mechanism(s) available to the mammalian brain. A selective afterdischarge threshold elevation concurrently observed is suspected to be a feline species\u2010specific effect.<\/jats:p>","DOI":"10.1111\/j.0013-9580.2004.19804.x","type":"journal-article","created":{"date-parts":[[2004,10,27]],"date-time":"2004-10-27T14:07:43Z","timestamp":1098886063000},"page":"1308-1316","source":"Crossref","is-referenced-by-count":3,"title":["Lasting Secondary Antiepileptogenesis Induced by Cingulate Kindling"],"prefix":"10.1111","volume":"45","author":[{"given":"Juhn 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