{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:22:08Z","timestamp":1790896928296,"version":"4.1.0"},"reference-count":74,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,9,29]],"date-time":"2004-09-29T00:00:00Z","timestamp":1096416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p><jats:bold>Summary:\u2002<\/jats:bold><jats:italic>Purpose:<\/jats:italic>This study examined the role of cognition, language, seizure\u2010related, and demographic variables in the psychopathology of children with complex partial seizure disorder (CPS) of average intelligence.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic>One\u2010hundred one CPS and 102 normal children, aged 5.1 to 16.9 years, had a structured psychiatric interview and cognitive and language testing. Parents provided demographic, perinatal, and seizure\u2010related information, as well as behavioral information through the Child Behavior Checklist (CBCL) and a structured psychiatric interview about the child.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic>Significantly more CPS patients had psychopathology, cognitive deficits, and linguistic deficits than did those in the normal group. Among the patients, Verbal IQ predicted the presence of a psychiatric diagnosis, as well as CBCL scores in the borderline\/clinical range. Seizure, linguistic, and demographic variables were unrelated to psychopathology. The cognitive and linguistic deficits of the CPS group, however, were predicted by seizure factors (e.g., prolonged seizures\/febrile convulsions; seizure frequency\/number of antiepileptic drugs) and demographic factors (e.g., minority status).<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic>Because subtle verbal cognitive deficits predict behavioral disturbances in pediatric CPSs, the study's findings highlight the importance of assessing behavior, cognition, and language in these children. They also underscore the negative impact of prolonged seizures, febrile convulsions, seizure frequency, and antiepileptic drug polytherapy on cognition and language in pediatric CPSs.<\/jats:p>","DOI":"10.1111\/j.0013-9580.2004.58703.x","type":"journal-article","created":{"date-parts":[[2004,9,29]],"date-time":"2004-09-29T13:51:28Z","timestamp":1096465888000},"page":"1273-1281","source":"Crossref","is-referenced-by-count":106,"title":["Psychopathology and Pediatric Complex Partial Seizures: Seizure\u2010related, Cognitive, and Linguistic Variables"],"prefix":"10.1111","volume":"45","author":[{"given":"Rochelle","family":"Caplan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabha","family":"Siddarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Gurbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raman","family":"Sankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Donald","family":"Shields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(88)90010-1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1992.tb01768.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1991.tb05109.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310100792"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.69.6.739"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1979.tb01621.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200108000-00012"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(69)90041-5"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162299001486"},{"key":"e_1_2_6_11_2","first-page":"143","article-title":"Academic achievement and the behavioral ratings in children with absence and complex partial epilepsy","volume":"19","author":"Williams J","year":"1996","journal-title":"Educ Treat Child"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199202000-00010"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1997.tb07374.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2003.18202.x"},{"key":"e_1_2_6_15_2","volume-title":"A neuropsychiatric study in childhood","author":"Rutter M","year":"1970"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1978.tb15256.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1996.tb00558.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199909000-00017"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1998.tb01427.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-198310000-00006"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1984.tb04399.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1542\/peds.85.6.1086","article-title":"Phenobarbital treatment and major depressive disorder in children with epilepsy: a naturalistic follow up","volume":"85","author":"Brent D","year":"1990","journal-title":"Pediatrics"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1054\/jocn.1999.0190"},{"key":"e_1_2_6_24_2","first-page":"471","article-title":"Psychosocial, behavioral, and medical outcome in children with epilepsy: a developmental risk factor model using longitudinal data","volume":"94","author":"Mitchell W","year":"1994","journal-title":"Pediatrics"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307380201700109"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2000.tb00097.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2779(2000)6:4<293::AID-MRDD8>3.0.CO;2-1"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1998.tb15457.x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140407"},{"key":"e_1_2_6_30_2","first-page":"562","article-title":"A prospective WISC\u2010R study in children with epilepsy","volume":"42","author":"Funakoshi A","year":"1988","journal-title":"Jpn J Psychiatric Neurol"},{"key":"e_1_2_6_31_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1469-8749.1986.tb03826.x","article-title":"Intellectual functions of patients with childhood\u2010onset epilepsy","volume":"26","author":"Rodin EA","year":"1986","journal-title":"Dev Med Child Neurol"},{"key":"e_1_2_6_32_2","first-page":"105","volume-title":"Academic achievement and school performance of children with epilepsy","author":"Seidenberg M","year":"1989"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.26101.x"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.70.5.424"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/08830738030180060501"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200108000-00019"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-7610.00286"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005192220001"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0021963099004084"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170004914X"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00217.x"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6974(95)00019-A"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150203"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1988.tb05182.x"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-6171.1988.tb00222.x"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1998.tb12357.x"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.6.648"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.2.250"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10089"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-20-08382.1998"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(00)00128-5"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200010)48:4<580::AID-ANA4>3.3.CO;2-2"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.17802.x"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1989.tb05316.x"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.2307\/3349632"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/8.2.360"},{"key":"e_1_2_6_57_2","volume-title":"Schedule for affective disorders and schizophrenia for school\u2010age children: epidemiologic version","author":"Orvaschel H","year":"1987"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199707000-00021"},{"key":"e_1_2_6_59_2","volume-title":"Diagnostic and statistical manual of mental disorders,","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_60_2","volume-title":"Manual for the Child Behavior Checklist and revised Child Behavior Profile","author":"Achenbach T","year":"1991"},{"key":"e_1_2_6_61_2","volume-title":"Wechsler Intelligence Scale for Children\u2013revised","author":"Wechsler D","year":"1974"},{"key":"e_1_2_6_62_2","volume-title":"Weschsler Intelligence Scale for Children","author":"Wechsler D","year":"1991"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1997.81.3f.1163"},{"key":"e_1_2_6_64_2","volume-title":"Test of language development\u20102 primary","author":"Newcomer PL","year":"1988"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.1.115"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00184.x"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1006\/ebeh.2000.0119"},{"key":"e_1_2_6_68_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1684\/j.1950-6945.2001.tb00464.x","article-title":"Epilepsy\u2010related ambiguity in rating the Child Behavior Checklist and the teacher's report form","volume":"3","author":"Oostrom K","year":"2001","journal-title":"Epileptic Disord"},{"key":"e_1_2_6_69_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.26002.x"},{"key":"e_1_2_6_70_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-6155.2002.tb00153.x"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2779(2000)6:4<268::AID-MRDD6>3.0.CO;2-B"},{"key":"e_1_2_6_72_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2003.48802.x"},{"key":"e_1_2_6_73_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617703930013"},{"key":"e_1_2_6_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb07100.x"},{"key":"e_1_2_6_75_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2003.25002.x"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0013-9580.2004.58703.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0013-9580.2004.58703.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T19:52:16Z","timestamp":1734551536000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0013-9580.2004.58703.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,29]]},"references-count":74,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["10.1111\/j.0013-9580.2004.58703.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0013-9580.2004.58703.x","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9,29]]}}}