{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:03:22Z","timestamp":1792476202471,"version":"4.5.0"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,9,29]],"date-time":"2004-09-29T00:00:00Z","timestamp":1096416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p><jats:bold>Summary:\u2002<\/jats:bold>  <jats:italic>Purpose:<\/jats:italic> One of the potential consequences of perinatal hypoxia\u2013ischemia (H\u2010I) is the development of epilepsy, and synaptic reorganization in the hippocampus has been associated with epilepsy after an injury. We tested the hypothesis that perinatal H\u2010I will induce spontaneous motor seizures, hippocampal lesions, and synaptic reorganization in the dentate gyrus.<\/jats:p><jats:p> <jats:italic>Methods:<\/jats:italic> The right common carotid artery of 7\u2010day\u2010old rats was permanently ligated, and the rats were placed for 120 min into a chamber filled with 8% oxygen (37\u00b0C). Animals were directly observed for chronic motor seizures for 7 to 24 months after the H\u2010I insult.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> Nearly half of the rats (i.e., eight of 20) were seen to have spontaneous motor seizures after the H\u2010I injury. The ipsilateral hippocampi from both the rats with seizures and the rats not seen to have seizures had hippocampal lesions and increased amounts of Timm stain in the inner molecular layer (IML) compared with controls. The contralateral hippocampi from the rats with seizures, but not the hippocampi from the rats not seen to have seizures, had significantly increased amounts of Timm stain in the IML.<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> These results suggest that perinatal H\u2010I can induce epilepsy, ipsilateral hippocampal lesions, and mossy fiber sprouting in the lesioned and contralateral hippocampus.<\/jats:p>","DOI":"10.1111\/j.0013-9580.2004.60403.x","type":"journal-article","created":{"date-parts":[[2004,9,29]],"date-time":"2004-09-29T13:51:28Z","timestamp":1096465888000},"page":"1210-1218","source":"Crossref","is-referenced-by-count":71,"title":["Epilepsy and Synaptic Reorganization in a Perinatal Rat Model of Hypoxia\u2013Ischemia"],"prefix":"10.1111","volume":"45","author":[{"given":"Philip A.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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