{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:29:53Z","timestamp":1785817793751,"version":"3.56.0"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,5,14]],"date-time":"2004-05-14T00:00:00Z","timestamp":1084492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p><jats:bold>Summary:\u2003<\/jats:bold>  <jats:italic>Purpose:<\/jats:italic> Voluntary hyperventilation has been advocated for many decades as an \u201cactivating\u201d procedure to provoke clinical seizures and epileptiform discharges in subjects with suspected epilepsy who undergo standard EEG recordings. This study was undertaken to determine the effects of hyperventilation in patients with proven epilepsy.<\/jats:p><jats:p> <jats:italic>Methods:<\/jats:italic> We examined the records of 433 consecutive patients with proven epilepsy, as documented by long\u2010term video\u2010EEG studies. The patients underwent 5 min of voluntary hyperventilation during standard EEG recordings. All EEGs were interpreted by board\u2010certified electroencephalographers. The patients ranged in age from 10 to 64 years; 384 (88.7%) had localization\u2010related and 48 (11.3%) generalized epilepsy syndromes.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> Hyperventilation was associated with a clinical seizure in two (0.46%) of the subjects (partial seizures in both cases). Interictal epileptiform discharges were interpreted as showing in increase in frequency during hyperventilation in 19 (4.4%) patients, when compared with the baseline EEG.<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> Voluntary hyperventilation in patients with unequivocal epilepsy is rarely associated with either clinical seizures or an increase in frequency of epileptiform discharges.<\/jats:p>","DOI":"10.1111\/j.0013-9580.2004.63803.x","type":"journal-article","created":{"date-parts":[[2004,5,14]],"date-time":"2004-05-14T13:43:22Z","timestamp":1084542202000},"page":"618-620","source":"Crossref","is-referenced-by-count":69,"title":["Does Hyperventilation Elicit Epileptic Seizures?"],"prefix":"10.1111","volume":"45","author":[{"given":"Mark D.","family":"Holmes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asanka S.","family":"Dewaraja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sampsa","family":"Vanhatalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,5,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01652503"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1936.02260120083006"},{"key":"e_1_2_5_4_2","first-page":"1","article-title":"Epilepsy and 3 per second spike and wave spike and wave rhythms","volume":"40","author":"Dalby M","year":"1969","journal-title":"Arch Neurol Scand"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1940.02280020070005"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1996.tb00592.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1977.00500180065014"},{"key":"e_1_2_5_8_2","first-page":"261","volume-title":"Electroencephalography: basic principles, clinical applications, and related fields","author":"Takahashi T"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-198704000-00001"},{"key":"e_1_2_5_10_2","volume-title":"pH and brain function","author":"Kaila K","year":"1998"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1994.tb01789.x"},{"key":"e_1_2_5_12_2","article-title":"Use of short\u2010term video\u2010EEG in the diagnosis of attack disorders","author":"McGonigal A","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0013-9580.2004.63803.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0013-9580.2004.63803.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T09:08:00Z","timestamp":1697360880000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0013-9580.2004.63803.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,14]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1111\/j.0013-9580.2004.63803.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0013-9580.2004.63803.x","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5,14]]}}}