{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:37:15Z","timestamp":1785818235548,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,8,24]],"date-time":"2004-08-24T00:00:00Z","timestamp":1093305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p><jats:bold>Summary:\u2002<\/jats:bold><jats:italic>Purpose:<\/jats:italic>To study the relation between the spike frequency during intraoperative electrocorticography (ECoG) under general anesthesia with isoflurane and that during extraoperative ECoG monitoring in children with intractable neocortical epilepsy.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic>Twenty\u2010one children (age, 1\u201316 years; 15 boys and six girls) who underwent intraoperative and extraoperative ECoG monitoring with subdural electrode arrays were studied. The spike frequency and the spatial pattern of spike frequency were compared between intraoperative and extraoperative ECoGs for each patient (by using Wilcoxon signed\u2010ranks and Spearman's rank correlation, respectively).<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic>In 15 of 21 patients, the spike frequency was significantly lower during intraoperative than during extraoperative ECoG (mean z =\u20136.3; p &lt; 0.001). In four of 21 patients, no significant difference was found in the spike frequency between intraoperative and extraoperative recordings. In two of 21 patients, spike frequency reached one spike\/min neither during intraoperative nor extraoperative recording; therefore appropriate comparison of spike frequency was not possible. A significant positive correlation in the spike\u2010frequency pattern was seen between intraoperative and extraoperative recordings in nine of nine cases who had \u226510 spikes\/min during intraoperative ECoG (mean rho\u2003=\u20030.62; p &lt; 0.01), in five of six cases with one to nine spikes\/min (mean rho\u2003=\u20030.50; p &lt; 0.01), and in none of five cases with less than one spike\/min (mean rho\u2003=\u20030.13).<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic>General anesthesia often decreases the spike frequency in children with neocortical epilepsy, yet intraoperative ECoG can reliably reflect the awake interictal spiking pattern when spike frequency exceeds one spike\/min during intraoperative ECoG recording.<\/jats:p>","DOI":"10.1111\/j.0013-9580.2004.65803.x","type":"journal-article","created":{"date-parts":[[2004,8,24]],"date-time":"2004-08-24T08:02:23Z","timestamp":1093334543000},"page":"1091-1099","source":"Crossref","is-referenced-by-count":51,"title":["Is Intraoperative Electrocorticography Reliable in Children with Intractable Neocortical Epilepsy?"],"prefix":"10.1111","volume":"45","author":[{"given":"Eishi","family":"Asano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"Benedek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aashit","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Juh\u00e1sz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagdish","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane 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