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Macrophage cells collected 3\u00a0days after viral infection had a flattened shape, with an increased number of large spikes of cytoplasm prolongations, giving an appearance of hairy cells. Cytopathological changes to the macrophage cells were similar regardless of the infecting flavivirus. Rough and smooth endoplasmic reticulum of the macrophage cells infected with flavivirus were abundant, hypertrophic and enlarged. A large number of free ribosomes were seen in the cytoplasm of these infected cells. Spherical particles approximately 50\u201370\u00a0nm in diameter, some of which were empty, were observed in the cytoplasm, generally inside vesicles. These particles probably correspond to viral particles.<\/jats:p>","DOI":"10.1111\/j.0022-2720.2004.01389.x","type":"journal-article","created":{"date-parts":[[2004,9,15]],"date-time":"2004-09-15T15:46:10Z","timestamp":1095263170000},"page":"5-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cytopathological changes induced by selected Brazilian flaviviruses in mouse macrophages"],"prefix":"10.1111","volume":"216","author":[{"given":"V. E. D.","family":"BARROS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"THOMAZINI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. T. 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