{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:48:27Z","timestamp":1775065707933,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,4,26]],"date-time":"2004-04-26T00:00:00Z","timestamp":1082937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> The immature infant immune system rarely makes RBC alloantibodies; however, most studies confirming the absence of alloantibodies in infants have involved transfusions that were matched for one of the most immunogenic antigens, rhesus D. The potential for D\u2013 infants to develop anti\u2010D is unknown. Specifically, this issue has not been analyzed for infants receiving whole\u2010blood\u2010derived PLTs from D+ donors. The importance of understanding such risk is underscored by the fact that anti\u2010D formation can be prevented by the administration of Rh immunoglobulin.<\/jats:p><jats:p><jats:bold>CASE REPORT:<\/jats:bold> A D\u2013 infant with congenital heart disease received two D\u2010mismatched whole\u2010blood\u2010derived PLT units at 17 weeks of age. He did not receive Rh immunoglobulin prophylaxis. Upon a subsequent admission 13 months later, anti\u2010D was identified in his plasma sample.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> The case presented here demonstrates that a young infant can respond to less than 0.6\u2003mL of D+ RBCs and documents the youngest patient to have developed a RBC alloantibody from a PLT transfusion. To prevent anti\u2010D formation, we recommend administering Rh immunoglobulin to all pediatric patients that receive PLT transfusions from D+ donors.<\/jats:p>","DOI":"10.1111\/j.0041-1132.2004.03370.x","type":"journal-article","created":{"date-parts":[[2004,4,26]],"date-time":"2004-04-26T09:44:22Z","timestamp":1082972662000},"page":"747-749","source":"Crossref","is-referenced-by-count":20,"title":["Platelet transfusion in an infant leading to formation of anti\u2010D: implications for immunoprophylaxis"],"prefix":"10.1111","volume":"44","author":[{"given":"Richard L.","family":"Haspel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorna","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R.","family":"Sloan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,4,26]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1986.26587020115.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/87.2.250"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40121463.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(76)80410-6"},{"key":"e_1_2_8_6_2","first-page":"13","article-title":"Neonatal cytomegalovirus infections: the relative role of neonatal blood transfusion and maternal exposure","volume":"7","author":"Rawls WE","year":"1984","journal-title":"Clin Invest Med"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1992.32292180151.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1984.24685066823.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1993.33193142319.x"},{"key":"e_1_2_8_10_2","volume-title":"Blood transfusion in clinical medicine.","author":"Mollison PL","year":"1997"},{"key":"e_1_2_8_11_2","volume-title":"Scientific basis of trans\u2010fusion medicine: implications for clinical practice","author":"Anderson KC","year":"2000"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/tmrv.2003.50003"},{"key":"e_1_2_8_13_2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.21307\/immunohematology-2019-680","article-title":"Immunoprophylaxis using intravenous Rh immune globulin should be standard practice when selected D\u2010negative patients are transfused with D\u2010positive random donor platelets","volume":"14","author":"Ewing CA","year":"1998","journal-title":"Immunohematology"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00074.x"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00015.x"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2000.02414.x"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/tmrv.2001.19953"},{"key":"e_1_2_8_18_2","volume-title":"Standards for blood banks and transfusion services.","author":"Gorlin JB","year":"2002"},{"key":"e_1_2_8_19_2","volume-title":"WinRho SDF package insert (Internet).","year":"2003"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0041-1132.2004.03370.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0041-1132.2004.03370.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0041-1132.2004.03370.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T03:45:11Z","timestamp":1697082311000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0041-1132.2004.03370.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,26]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1111\/j.0041-1132.2004.03370.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0041-1132.2004.03370.x","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,26]]}}}