{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:37:42Z","timestamp":1761154662479},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,8,17]],"date-time":"2004-08-17T00:00:00Z","timestamp":1092700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p><jats:bold>BACKGROUND<\/jats:bold> Red blood cell (RBC) components from donors with sickle cell trait (Hb AS) often occlude white blood cell (WBC) reduction filters. Techniques were investigated to successfully filter Hb AS donor blood by increasing the Hb oxygen saturation with storage bags and conditions suitable for transfusion products.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:\u2002<\/jats:bold> Oxygenation kinetics were measured over 3\u2003days in whole\u2010blood units stored in standard\u2010sized 600\u2010mL polyvinylchloride (PVC) bags and whole\u2010blood units divided into three equal parts and stored in standard\u2010sized blood bags made from PVC, tri\u20102\u2010(ethylhexyl)trimellitate (CLX) plastic, or Teflon. The filterability of Hb AS blood stored for 3\u2003days was tested with whole\u2010blood filters.<\/jats:p><jats:p><jats:bold>RESULTS:\u2002<\/jats:bold> Oxygen saturation levels did not increase in full whole\u2010blood units from donors without sickle cell trait during 3\u2003days of storage in 600\u2010mL PVC bags. In divided Hb AS whole\u2010blood units stored for 3\u2003days, oxygen saturation levels increased from baseline levels of 45 to 56, 66, and 94\u2003percent after storage in 600\u2010mL PVC, CLX, and Teflon bags, respectively (n\u2003=\u20035, p\u2003&lt;\u20030.02), and all components filtered completely. When full Hb AS whole\u2010blood units from eight donors were stored for 3\u2003days in 1.5\u2010L CLX bags, all units filtered completely, but one had a high residual WBC count.<\/jats:p><jats:p><jats:bold>CONCLUSION:\u2002<\/jats:bold> Storage of Hb AS whole blood in large\u2010capacity oxygen\u2010permeable bags increases oxygen tension and allows more effective WBC reduction by filtration.<\/jats:p>","DOI":"10.1111\/j.0041-1132.2004.04086.x","type":"journal-article","created":{"date-parts":[[2004,8,17]],"date-time":"2004-08-17T09:10:39Z","timestamp":1092733839000},"page":"1293-1299","source":"Crossref","is-referenced-by-count":15,"title":["Increasing hemoglobin oxygen saturation levels in sickle trait donor whole blood prevents hemoglobin S polymerization and allows effective white blood cell reduction by filtration"],"prefix":"10.1111","volume":"44","author":[{"given":"David F.","family":"Stroncek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen M.","family":"Byrne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance T.","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan N.","family":"Schechter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan F.","family":"Leitman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,17]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-7963(00)80114-5"},{"key":"e_1_2_7_3_2","first-page":"381","article-title":"Leukocyte\u2010reduced blood products","volume":"5","author":"Kadar JG","year":"1998","journal-title":"Transfus Med"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.1997.73100543.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-3886(98)00056-3"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-3886(00)00017-5"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41101192.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2003.00669.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00206.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04464.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(84)84263-0"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113504"},{"key":"e_1_2_7_13_2","doi-asserted-by":"crossref","unstructured":"NoguchiCT HaleyJD AbrahamDJ SchechterAN.Inhibition of sickle hemoglobin polymerization as a basis for therapeutic approaches to sickle cell anemia. In:AbrahamDJ ed.Burger's medicinal chemistry and drug discovery.6th ed. Vol. III Chapter 9. New York:Wiley;2003:443\u201079.","DOI":"10.1002\/0471266949.bmc050"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0041-1132.2004.04086.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0041-1132.2004.04086.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0041-1132.2004.04086.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T02:15:14Z","timestamp":1697249714000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0041-1132.2004.04086.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,17]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1111\/j.0041-1132.2004.04086.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0041-1132.2004.04086.x","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8,17]]}}}