{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:47:14Z","timestamp":1772160434375,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T00:00:00Z","timestamp":1137542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background:\u2002<\/jats:bold>\n                    <jats:italic>Helicobacter<\/jats:italic>\n                    species are associated with inflammatory bowel disease in rodents and in nonhuman primates. Therefore, we prospectively investigated the presence of\n                    <jats:italic>Helicobacter<\/jats:italic>\n                    species in the intestinal mucosa of patients with and without Crohn's disease by culture and polymerase chain reaction (PCR) assays.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and Methods:\u2002<\/jats:bold>\n                    Mucosal fragments were obtained from the ileum, different colon regions, and rectum of 43 patients with Crohn's disease and of 74 patients without inflammatory bowel disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    strains, identified by 16S rRNA gene sequencing, were more frequently isolated and PCR\u2010detected in the intestinal mucosa of patients with ulcerative colitis\u2010like Crohn's disease than in intestinal mucosa of the control group. Otherwise, anti\u2010\n                    <jats:italic>H.\u00a0pylori<\/jats:italic>\n                    immunoglobulin G levels were significantly lower in fibrostenosing and fistulating Crohn's disease subgroups. No other\n                    <jats:italic>Helicobacter<\/jats:italic>\n                    species were found in the intestinal mucosa of the patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    Although our results suggest an association between the presence of\n                    <jats:italic>H.\u00a0pylori<\/jats:italic>\n                    in the intestine and ulcerative colitis\u2010like phenotype of Crohn's disease,\n                    <jats:italic>H.\u00a0pylori<\/jats:italic>\n                    infection in the actual causality of Crohn's disease is still to be determined.\n                  <\/jats:p>","DOI":"10.1111\/j.0083-8703.2006.00368.x","type":"journal-article","created":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T09:24:21Z","timestamp":1137576261000},"page":"2-9","source":"Crossref","is-referenced-by-count":41,"title":["Isolation of\n                    <i>Helicobacter pylori<\/i>\n                    from the Intestinal Mucosa of Patients with Crohn's Disease"],"prefix":"10.1111","volume":"11","author":[{"given":"Adriana Gon\u00e7alves","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gifone Aguiar","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia Maria Camargos","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria das Gra\u00e7as Pimenta","family":"Sanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00edlvia Beleza","family":"Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Dani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederico Passos","family":"Marinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liano Sia","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de Lourdes Abreu","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facia Porto Fonseca","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dulciene Maria Magalh\u00e3es","family":"Queiroz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0889-8553(21)00207-7","article-title":"Current concepts of the etiology and pathogenesis of ulcerative colitis and Crohn's disease","volume":"24","author":"Sartor RB","year":"1997","journal-title":"Gastroenterol Clin North Am"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.3780060103"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb03836.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(01)00004-8"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1128\/iai.65.11.4858-4864.1997","article-title":"Helicobacter bilis induced inflammatory bowel disease (IBD) in defined flora scid mice","volume":"65","author":"Shomer NH","year":"1997","journal-title":"Infect Immun"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.11.5157-5166.1998"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.9.3673-3681.1996"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.1.146-151.1999"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-50-5-421"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8536845"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009728200"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.35393"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32413"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01703.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.6.2766-2768.2004"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.2.874-876.2004"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8964407"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","unstructured":"QueirozDMM SantosA OliveiraAG RochaGA MouraSB CamargosERS VallePR BicalhoLAF DaneR. 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