{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:24:49Z","timestamp":1777454689348,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T00:00:00Z","timestamp":1137542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold>  <jats:italic>Helicobacter\u00a0pylori<\/jats:italic> infection in Mongolian gerbils is an established experimental model of gastric carcinogenesis that mimics <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive patients developing gastric ulcer and gastric cancer, but the effect of probiotic therapy on functional aspects of this infection remains unknown.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We compared the effects of intragastric inoculation of gerbils with <jats:italic>H.\u00a0pylori<\/jats:italic> strain (<jats:italic>cagA<\/jats:italic><jats:sup>+<\/jats:sup><jats:italic> vacA<\/jats:italic><jats:sup>+<\/jats:sup>, 5\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup> colony forming units\/ml) with or without triple therapy including omeprazole, amoxicillin, and tinidazol or probiotic bacteria Lacidofil. Histology of glandular mucosa, the viable <jats:italic>H.\u00a0pylori<\/jats:italic>, <jats:italic>and<\/jats:italic> density of <jats:italic>H.\u00a0pylori<\/jats:italic> colonization were evaluated. The gastric blood flow was measured by H<jats:sub>2<\/jats:sub>\u2010gas clearance method; the plasma gastrin and gastric luminal somatostatin were determined by RIA and expression of cyclooxygenase (COX)\u20102 and apoptotic Bax and Bcl\u20102 proteins were evaluated by Western blot.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The gastric <jats:italic>H.\u00a0pylori<\/jats:italic> infection was detected in all animals by histology and <jats:italic>H.\u00a0pylori<\/jats:italic> culture. Basal gastric acid was significantly reduced in <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010infected animals but not in those with triple therapy or Lacidofil. Early lesions were seen already 4\u00a0weeks upon <jats:italic>H.\u00a0pylori<\/jats:italic> inoculation and consisted of chronic gastritis and glandular atypia associated with typical regenerative hyperplasia and increased mitotic activity and formation of apoptotic bodies. The <jats:italic>H.\u00a0pylori<\/jats:italic> infection was accompanied by the fall in gastric blood flow, the marked increase in plasma gastrin, the significant fall in gastric somatostatin levels and Bcl\u20102 protein expression, and the rise in expression of COX\u20102 and Bax proteins. These mucosal changes were counteracted by the triple therapy and Lacidofil.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>  <jats:italic>H.\u00a0pylori<\/jats:italic> infection in gerbils, associated with regenerative hyperplasia of glandular structure, results in the suppression of gastric secretion, overexpression of COX\u20102, and enhancement in apoptosis and impairment of both, gastric blood flow and gastrin\u2013somatostatin link that were reversed by anti\u2010<jats:italic>H.\u00a0pylori<\/jats:italic> triple therapy and attenuated by probiotics.<\/jats:p>","DOI":"10.1111\/j.0083-8703.2006.00373.x","type":"journal-article","created":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T14:24:21Z","timestamp":1137594261000},"page":"10-20","source":"Crossref","is-referenced-by-count":42,"title":["Effect of Probiotics and Triple Eradication Therapy on the Cyclooxygenase (COX)\u20102 Expression, Apoptosis, and Functional Gastric Mucosal Impairment in <i> Helicobacter pylori<\/i>\u2010Infected Mongolian Gerbils"],"prefix":"10.1111","volume":"11","author":[{"given":"Tomasz","family":"Brzozowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Konturek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzena","family":"Mierzwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danuta","family":"Drozdowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wladyslaw","family":"Bielanski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slawomir","family":"Kwiecien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislaw 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