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In this infection, parasite eggs are the primary stimulus for Th2 response development. Recent work has shown that egg molecules exert multiple levels of control over the development of host interferon\u2010\u03b3\u2010associated inflammatory responses. Soluble egg antigen inhibits the ability of dendritic cells to make interleukin\u201012 and induces Th2\u2010polarized adaptive immune responses that in combination with regulatory T\u2010cell responses effectively limit Th1 response development. In this article, we discuss the factors influencing Th2 response polarization during infection with <jats:italic>S. mansoni.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.0105-2896.2004.00187.x","type":"journal-article","created":{"date-parts":[[2004,9,10]],"date-time":"2004-09-10T14:18:34Z","timestamp":1094825914000},"page":"117-126","source":"Crossref","is-referenced-by-count":160,"title":["Th2 response polarization during infection with the helminth parasite <i>Schistosoma mansoni<\/i>"],"prefix":"10.1111","volume":"201","author":[{"given":"Edward J.","family":"Pearce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"M. Kane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"J. 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