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This family regulates the expression of multiple genes, whose products include cytokines, chemokines, adhesion molecules, and antiapoptotic factors that are important components of the innate and adaptive immune response. A prominent role of NF\u2010\u03baB transcription factors in resistance to a variety of infectious diseases was revealed by studies with mice that lack individual family members. However, little is known about the basis for these effects or about the role of individual family members during a coordinated immune response to infection. Diverse parasites such as <jats:italic>Toxoplasma gondii<\/jats:italic>, <jats:italic>Leishmania major<\/jats:italic>, and <jats:italic>Trichuris muris<\/jats:italic> provide a unique opportunity to understand the role of the NF\u2010\u03baB system in the development of innate and adaptive immunity to these infections. The basis for resistance and susceptibility to these parasites is well understood, and studies using these experimental systems have provided unique insights into the role of NF\u2010\u03baB in the regulation of T\u2010helper 1 cell (Th1) and Th2 type responses. It has become clear that NF\u2010\u03baB family members have cell lineage\u2010specific functions and that their relative importance varies with type of infection as well as route of pathogen entry. Thus, studies with models of parasitic infection have revealed that individual NF\u2010\u03baB family members perform distinct, nonoverlapping, and biologically significant functions in the regulation of immunity and inflammation.<\/jats:p>","DOI":"10.1111\/j.0105-2896.2004.00189.x","type":"journal-article","created":{"date-parts":[[2004,9,10]],"date-time":"2004-09-10T14:18:34Z","timestamp":1094825914000},"page":"48-56","source":"Crossref","is-referenced-by-count":53,"title":["New lessons from old pathogens: what parasitic infections have taught us about the role of nuclear factor\u2010\u03baB in the regulation of immunity"],"prefix":"10.1111","volume":"201","author":[{"given":"Nicola J.","family":"Mason","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Artis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.16.1.225"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.621"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-5323(03)00034-4"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","unstructured":"RothwarfDM KarinM.The NF\u2010\u03baB activation pathway: a paradigm in information transfer from membrane to nucleus. 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