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Although multiple reports have addressed several aspects of pre\u2010TCR signaling and function, its ability to regulate diverse functions, including proliferation, survival, and allelic exclusion of the TCR\u2010\u03b2 locus, remains an open question. What fascinates us is its central role in the fine balance between physiological differentiation and thymocyte transformation that leads to T\u2010cell leukemia and lymphomas. In this review, we integrate pre\u2010TCR signaling pathways and study their effects on the regulation of T\u2010cell progenitor cell\u2010cycle entry and cell survival. We also connect aberrant pre\u2010TCR signaling to deregulated proliferation and apoptotic balances and thymocyte transformation.<\/jats:p>","DOI":"10.1111\/j.0105-2896.2006.00343.x","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T13:54:13Z","timestamp":1138715653000},"page":"159-169","source":"Crossref","is-referenced-by-count":82,"title":["Regulation of T\u2010cell progenitor survival and cell\u2010cycle entry by the pre\u2010T\u2010cell 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