{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:46:34Z","timestamp":1791103594406,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,21]],"date-time":"2006-07-21T00:00:00Z","timestamp":1153440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold>Summary:\u2002<\/jats:bold> The CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> regulatory T cells (Tregs) are efficient regulators of autoimmunity, but the mechanism remains elusive. We summarize recent data for the conclusion that disease\u2010specific Tregs respond to tissue antigens to maintain physiological tolerance and prevent autoimmunity. First, polyclonal Tregs from antigen\u2010positive donors suppress autoimmune ovarian disease (AOD) or experimental autoimmune prostatitis in day 3 thymectomized (d3tx) mice more efficiently than Tregs from antigen\u2010negative donors. Second, Tregs of antigen\u2010negative adult mice respond to cognate antigen <jats:italic>in vivo<\/jats:italic> and rapidly gain disease\u2010specific Treg function. Third, in d3tx female recipients devoid of neonatal ovarian antigens, only female Tregs suppressed AOD; the male Tregs gain AOD\u2010suppressing function by responding to the ovarian antigen in the recipients and mask the supremacy of female Tregs in AOD suppression. Fourth, when Tregs completely suppress AOD, the ovary\u2010draining lymph node is the only location with evidence of profound and persistent (but reversible) host T\u2010cell suppression. Fifth, from these nodes, highly potent AOD\u2010suppressing Tregs are retrievable. We conclude that self\u2010tolerance involves the continuous priming of Tregs by autoantigens, and in autoimmune disease suppression, the effector T\u2010cell response is continuously negated by potent disease\u2010specific Tregs that accumulate at the site of autoantigen presentation.<\/jats:p>","DOI":"10.1111\/j.0105-2896.2006.00404.x","type":"journal-article","created":{"date-parts":[[2006,7,22]],"date-time":"2006-07-22T01:51:11Z","timestamp":1153533071000},"page":"170-184","source":"Crossref","is-referenced-by-count":59,"title":["The role of physiological self\u2010antigen in the acquisition and maintenance of regulatory T\u2010cell function"],"prefix":"10.1111","volume":"212","author":[{"given":"Eileen T.","family":"Samy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulius Y.","family":"Setiady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patcharin","family":"Pramoonjago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth S. 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