{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:52:32Z","timestamp":1794012752654,"version":"4.8.0"},"reference-count":154,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,21]],"date-time":"2006-07-21T00:00:00Z","timestamp":1153440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold>Summary:\u2002<\/jats:bold> Naturally arising CD25<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup> regulatory T (Treg) cells, most of which are produced by the normal thymus as a functionally mature T\u2010cell subpopulation, play key roles in the maintenance of immunologic self\u2010tolerance and negative control of a variety of physiological and pathological immune responses. Natural Tregs specifically express Foxp3, a transcription factor that plays a critical role in their development and function. Complete depletion of Foxp3\u2010expressing natural Tregs, whether they are CD25<jats:sup>+<\/jats:sup> or CD25<jats:sup>\u2013<\/jats:sup>, activates even weak or rare self\u2010reactive T\u2010cell clones, inducing severe and widespread autoimmune\/inflammatory diseases. Natural Tregs are highly dependent on exogenously provided interleukin (IL)\u20102 for their survival in the periphery. In addition to Foxp3 and IL\u20102\/IL\u20102 receptor, deficiency or functional alteration of other molecules, expressed by T cells or non\u2010T cells, may affect the development\/function of Tregs or self\u2010reactive T cells, or both, and consequently tip the peripheral balance between the two populations toward autoimmunity. Elucidation of the molecular and cellular basis of this Treg\u2010mediated active maintenance of self\u2010tolerance will facilitate both our understanding of the pathogenetic mechanism of autoimmune disease and the development of novel methods of autoimmune disease prevention and treatment via enhancing and re\u2010establishing Treg\u2010mediated dominant control over self\u2010reactive T cells.<\/jats:p>","DOI":"10.1111\/j.0105-2896.2006.00427.x","type":"journal-article","created":{"date-parts":[[2006,7,22]],"date-time":"2006-07-22T01:51:11Z","timestamp":1153533071000},"page":"8-27","source":"Crossref","is-referenced-by-count":1330,"title":["Foxp3<sup>+<\/sup>CD25<sup>+<\/sup>CD4<sup>+<\/sup> natural regulatory T cells in dominant self\u2010tolerance and autoimmune disease"],"prefix":"10.1111","volume":"212","author":[{"given":"Shimon","family":"Sakaguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruka","family":"Setoguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Fehervari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,21]]},"reference":[{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141122"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.423"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni0901-816"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.3.1151"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2001.1820115.x"},{"key":"e_1_2_14_7_2","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.4049\/jimmunol.162.9.5317","article-title":"Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self\u2010tolerance","volume":"162","author":"Itoh M","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(99)01559-5"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030152"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040249"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/86302"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1318"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/0470871628.ch2"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030686"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/10.12.1969"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00415.x"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1180"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079490"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni904"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni909"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/83784"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11679"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/83707"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/83713"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh165"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.2.306"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302567"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.01.016"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050157"},{"key":"e_1_2_14_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050784"},{"key":"e_1_2_14_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.2.387"},{"key":"e_1_2_14_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00231.x"},{"key":"e_1_2_14_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.6.3105"},{"key":"e_1_2_14_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.8.4748"},{"key":"e_1_2_14_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260125"},{"key":"e_1_2_14_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404870101"},{"key":"e_1_2_14_37_2","first-page":"147","article-title":"Role of genetic factors in organ\u2010specific autoimmune diseases induced by manipulating the thymus or T cells, and not self\u2010antigens","volume":"2","author":"Sakaguchi S","year":"2000","journal-title":"Rev Immunogenet"},{"key":"e_1_2_14_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.01.060"},{"key":"e_1_2_14_39_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01940.x"},{"key":"e_1_2_14_40_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031080"},{"key":"e_1_2_14_41_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.10.5967"},{"key":"e_1_2_14_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.8.537"},{"key":"e_1_2_14_43_2","first-page":"203","volume-title":"Autoimmunity: Physiology and Disease.","author":"Sakaguchi S","year":"1994"},{"key":"e_1_2_14_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2004.03.012"},{"key":"e_1_2_14_45_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-4051"},{"key":"e_1_2_14_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/352621a0"},{"key":"e_1_2_14_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1995.tb00092.x"},{"key":"e_1_2_14_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90180-9"},{"key":"e_1_2_14_49_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.11.1561"},{"key":"e_1_2_14_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.7.3168"},{"key":"e_1_2_14_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1263"},{"key":"e_1_2_14_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200106)31:6<1637::AID-IMMU1637>3.0.CO;2-T"},{"key":"e_1_2_14_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00367-9"},{"key":"e_1_2_14_54_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.9.4850"},{"key":"e_1_2_14_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1264"},{"key":"e_1_2_14_56_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.11.6519"},{"key":"e_1_2_14_57_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041982"},{"key":"e_1_2_14_58_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.132254399"},{"key":"e_1_2_14_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2003.09.013"},{"key":"e_1_2_14_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/5941"},{"key":"e_1_2_14_61_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1999.0609"},{"key":"e_1_2_14_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.09.013"},{"key":"e_1_2_14_63_2","doi-asserted-by":"publisher","DOI":"10.1086\/429843"},{"key":"e_1_2_14_64_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.7.3435"},{"key":"e_1_2_14_65_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.5853"},{"key":"e_1_2_14_66_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4049\/jimmunol.142.2.471","article-title":"Organ\u2010specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease","volume":"142","author":"Sakaguchi S","year":"1989","journal-title":"J Immunol"},{"key":"e_1_2_14_67_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.1.1"},{"key":"e_1_2_14_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.11.002"},{"key":"e_1_2_14_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2006.01.005"},{"key":"e_1_2_14_70_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050855"},{"key":"e_1_2_14_71_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030422"},{"key":"e_1_2_14_72_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040139"},{"key":"e_1_2_14_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh122"},{"key":"e_1_2_14_74_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.2.303"},{"key":"e_1_2_14_75_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.2.295"},{"key":"e_1_2_14_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80195-8"},{"key":"e_1_2_14_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425143"},{"key":"e_1_2_14_78_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.3.427"},{"key":"e_1_2_14_79_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.4.1852"},{"key":"e_1_2_14_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni846"},{"key":"e_1_2_14_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1003"},{"key":"e_1_2_14_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1457"},{"key":"e_1_2_14_83_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403342101"},{"key":"e_1_2_14_84_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505802102"},{"key":"e_1_2_14_85_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1533209100"},{"key":"e_1_2_14_86_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200526168"},{"key":"e_1_2_14_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00110-4"},{"key":"e_1_2_14_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni759"},{"key":"e_1_2_14_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00280-7"},{"key":"e_1_2_14_90_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425818"},{"key":"e_1_2_14_91_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.8.5008"},{"key":"e_1_2_14_92_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.10.5823"},{"key":"e_1_2_14_93_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2334901100"},{"key":"e_1_2_14_94_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.1.353"},{"key":"e_1_2_14_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00327-3"},{"key":"e_1_2_14_96_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425810"},{"key":"e_1_2_14_97_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104533"},{"key":"e_1_2_14_98_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.1059"},{"key":"e_1_2_14_99_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.1316"},{"key":"e_1_2_14_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng927"},{"key":"e_1_2_14_101_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041538"},{"key":"e_1_2_14_102_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1078231"},{"key":"e_1_2_14_103_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh178"},{"key":"e_1_2_14_104_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042276"},{"key":"e_1_2_14_105_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh126"},{"key":"e_1_2_14_106_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.11.6526"},{"key":"e_1_2_14_107_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040685"},{"key":"e_1_2_14_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02119"},{"key":"e_1_2_14_109_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069057"},{"key":"e_1_2_14_110_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069066"},{"key":"e_1_2_14_111_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041869"},{"key":"e_1_2_14_112_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050903"},{"key":"e_1_2_14_113_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.4.397"},{"key":"e_1_2_14_114_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075958"},{"key":"e_1_2_14_115_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.4.1862"},{"key":"e_1_2_14_116_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050471"},{"key":"e_1_2_14_117_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni906"},{"key":"e_1_2_14_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.07.005"},{"key":"e_1_2_14_119_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.4.2067"},{"key":"e_1_2_14_120_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1105677"},{"key":"e_1_2_14_121_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535240"},{"key":"e_1_2_14_122_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm960"},{"key":"e_1_2_14_123_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916939908994073"},{"key":"e_1_2_14_124_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.5.3025"},{"key":"e_1_2_14_125_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.9.4712"},{"key":"e_1_2_14_126_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.5.3111"},{"key":"e_1_2_14_127_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404444101"},{"key":"e_1_2_14_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01299-7"},{"key":"e_1_2_14_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01217-6"},{"key":"e_1_2_14_130_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200114235"},{"key":"e_1_2_14_131_2","doi-asserted-by":"publisher","DOI":"10.1038\/86283"},{"key":"e_1_2_14_132_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507454102"},{"key":"e_1_2_14_133_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90348-8"},{"key":"e_1_2_14_134_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0895(199607)12:2<103::AID-DMR157>3.0.CO;2-2"},{"key":"e_1_2_14_135_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.412702"},{"key":"e_1_2_14_136_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.7.4081"},{"key":"e_1_2_14_137_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.33.7.700"},{"key":"e_1_2_14_138_2","first-page":"362","article-title":"Thyroiditis in T cell\u2010depleted rats. Influence of strain, radiation dose, adjuvants and antilymphocyte serum","volume":"21","author":"Penhale WJ","year":"1975","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_14_139_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.3.627"},{"key":"e_1_2_14_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(00)00163-1"},{"key":"e_1_2_14_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00202-3"},{"key":"e_1_2_14_142_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.8.4040"},{"key":"e_1_2_14_143_2","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1999.0272"},{"key":"e_1_2_14_144_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2235552100"},{"key":"e_1_2_14_145_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.4.2651"},{"key":"e_1_2_14_146_2","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.4049\/jimmunol.152.5.2586","article-title":"Ionizing radiation and autoimmunity. Induction of autoimmune disease in mice by high dose fractionated total lymphoid irradiation and its prevention by inoculating normal T cells","volume":"152","author":"Sakaguchi N","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_14_147_2","doi-asserted-by":"crossref","first-page":"5309","DOI":"10.4049\/jimmunol.162.9.5309","article-title":"Virus and autoimmunity: induction of autoimmune disease in mice by mouse T lymphotropic virus (MTLV) destroying CD4+ T cells","volume":"162","author":"Morse SS","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_14_148_2","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.4049\/jimmunol.152.3.1471","article-title":"Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression","volume":"152","author":"Sakaguchi S","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_14_149_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830250139"},{"key":"e_1_2_14_150_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1323"},{"key":"e_1_2_14_151_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1673"},{"key":"e_1_2_14_152_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20032158"},{"key":"e_1_2_14_153_2","first-page":"1129","article-title":"CD4(+) CD25(+) T\u2010cell production in healthy humans and in patients with thymic hypoplasia","volume":"9","author":"Sullivan KE","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_14_154_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)90057-2"},{"key":"e_1_2_14_155_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00248.x"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0105-2896.2006.00427.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0105-2896.2006.00427.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T07:39:03Z","timestamp":1697355543000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0105-2896.2006.00427.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,21]]},"references-count":154,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.0105-2896.2006.00427.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0105-2896.2006.00427.x","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,21]]}}}