{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:46:05Z","timestamp":1777430765379,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T00:00:00Z","timestamp":1080000000000},"content-version":"vor","delay-in-days":143,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p> <jats:italic>Although the importance of CD8<jats:sup>+<\/jats:sup> T cells for vaccination and immunity to reinfection with <\/jats:italic>Leishmania<jats:italic> parasites is well established, their role in primary infections is disputed. In the present study we further characterized the role of CD8<jats:sup>+<\/jats:sup> T cells in primary <\/jats:italic>L.\u00a0major<jats:italic> infections. We used two groups of <\/jats:italic>L.\u00a0major<jats:italic> infected BALB\/c mice: both groups were immunomanipulated to heal and in one group CD8<jats:sup>+<\/jats:sup> T cells were depleted throughout the course of infection. Our results show that the reversal of healing caused by the absence of CD8<jats:sup>+<\/jats:sup> T cells did not alter the proliferation of CD4<jats:sup>+<\/jats:sup> T cells, however, the frequency of CD4<jats:sup>+<\/jats:sup> T cells expressing IFN\u2010\u03b3 as well as the levels of this cytokine were clearly reduced. These lower levels of IFN\u2010\u03b3 correlated with a higher parasite load. Our results show that transient depletion of CD4<jats:sup>+<\/jats:sup> T cells allows the establishment of an equilibrium between CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cells and allows CD8<jats:sup>+<\/jats:sup> T cell activation and effector functions to develop. In addition, our results suggest that cross\u2010talk between CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cells is crucial for the host defence against <\/jats:italic>L.\u00a0major.<\/jats:p>","DOI":"10.1111\/j.0141-9838.2004.00668.x","type":"journal-article","created":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T09:44:45Z","timestamp":1080035085000},"page":"559-567","source":"Crossref","is-referenced-by-count":37,"title":["Cross\u2010talk between CD8<sup>+<\/sup> and CD4<sup>+<\/sup> T cells in experimental cutaneous leishmaniasis: CD8<sup>+<\/sup> T cells are required for optimal IFN\u2010\u03b3 production by CD4<sup>+<\/sup> T cells"],"prefix":"10.1111","volume":"25","author":[{"given":"Shanthi","family":"Herath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Kropf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/35021239"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri933"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(98)80121-0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.13.040195.001055"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/jlb.49.1.73","article-title":"Killing of Leishmania parasites in activated murine macrophages is based on an 1\u2010arginine\u2010dependent process that produces nitrogen derivatives","volume":"49","author":"Mauel J","year":"1991","journal-title":"J Leuk Biol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830211216"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.3.783"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1001-907"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200009)30:9<2669::AID-IMMU2669>3.0.CO;2-1"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.11.5347"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri978"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-3-7"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830221206"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1128\/iai.61.9.3730-3738.1993","article-title":"Gamma\u2010interferon response in secondary Leishmania major infection. 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