{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:02:04Z","timestamp":1758124924432},"reference-count":25,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T00:00:00Z","timestamp":1080000000000},"content-version":"vor","delay-in-days":143,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p> <jats:italic>An attenuated line of<\/jats:italic> Leishmania mexicana <jats:italic>(the<\/jats:italic> L.\u00a0mexicana <jats:italic>H\u2010line) has been established by culturing<\/jats:italic> in vitro <jats:italic>under gentamicin pressure<\/jats:italic><jats:italic>. BALB\/c mice infected with the<\/jats:italic> L.\u00a0mexicana <jats:italic>H\u2010line developed a CD4<\/jats:italic><jats:sup><jats:italic>+<\/jats:italic><\/jats:sup><jats:italic>Th1\u2010like response, indicated by the cytokine profile of their splenocytes stimulated by<\/jats:italic> L.\u00a0mexicana <jats:italic>wild\u2010type (WT) promastigotes. This profile is sustained after these mice are challenged with<\/jats:italic> L.\u00a0mexicana <jats:italic>WT. Control mice infected with<\/jats:italic> L.\u00a0mexicana <jats:italic>WT alone developed a CD4<\/jats:italic><jats:sup><jats:italic>+<\/jats:italic><\/jats:sup><jats:italic>Th2\u2010like cytokine profile.<\/jats:italic><jats:italic>In mice immunized with L.\u00a0mexicana H\u2010line and then challenged with WT\u2010line, were eliminated when immunizing H\u2010line parasites persisted in the skin and draining popliteal lymph nodes (PLNs). In experiments in which mice were inoculated with attenuated and WT parasites at the same time, either at the same site or on separate sides of the mouse, growth of the WT parasites was significantly contained and controlled, indicating a possible therapeutic role for the attenuated parasites.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.0141-9838.2004.00671.x","type":"journal-article","created":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T09:44:45Z","timestamp":1080035085000},"page":"589-596","source":"Crossref","is-referenced-by-count":10,"title":["<i>Leishmania mexicana<\/i> H\u2010line attenuated under pressure of gentamicin, potentiates a Th1 response and control of cutaneous leishmaniasis in BALB\/c mice"],"prefix":"10.1111","volume":"25","author":[{"given":"Hamid","family":"Daneshvar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Hagan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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