{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:07:40Z","timestamp":1791198460019,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"8-9","license":[{"start":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T00:00:00Z","timestamp":1106870400000},"content-version":"vor","delay-in-days":180,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p> <jats:italic>In the BALB\/c mouse model, primary infection with<\/jats:italic> Toxoplasma gondii <jats:italic>during the second third of gestation leads to a high percentage of infected foetuses. However, immunity induced by infection contracted before pregnancy prevents parasites from crossing the placenta and completely protects the foetuses, as well as the pregnant women. In order to clarify the roles of CD4<\/jats:italic><jats:sup><jats:italic>+<\/jats:italic><\/jats:sup><jats:italic>, CD8<\/jats:italic><jats:sup><jats:italic>+<\/jats:italic><\/jats:sup><jats:italic>T lymphocytes and IFN\u2010\u03b3 in this protection, pregnant BALB\/c mice were treated with depleting monoclonal antibodies against CD4, CD8, IFN\u2010\u03b3, or control antibody. Only the foetuses of the groups treated with anti\u2010CD8 and anti\u2010IFN\u2010\u03b3 antibodies developed congenital toxoplasmosis. The maternal production of IFN\u2010\u03b3 was depressed in the mice depleted of CD4 and CD8 cells (<\/jats:italic>P\u00a0&lt;\u00a0<jats:italic>0\u00b7001). Determination of the blood parasite load demonstrated that materno\u2010foetal transmission of<\/jats:italic> T.\u00a0gondii <jats:italic>correlates with maternal parasitaemia. Together, these results show that CD8<\/jats:italic><jats:sup><jats:italic>+<\/jats:italic><\/jats:sup><jats:italic>T lymphocytes and IFN\u2010\u03b3 play an important role in protection against congenital toxoplasmosis during reinfection.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.0141-9838.2004.00713.x","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T18:33:28Z","timestamp":1106937208000},"page":"315-318","source":"Crossref","is-referenced-by-count":41,"title":["Role of gamma interferon and T cells in congenital <i>Toxoplasma<\/i> transmission"],"prefix":"10.1111","volume":"26","author":[{"given":"A.","family":"Abou\u2010Bacar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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