{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:22:13Z","timestamp":1759936933418},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T00:00:00Z","timestamp":1109894400000},"content-version":"vor","delay-in-days":154,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p> <jats:italic>The study was aimed at identifying pro\u2010 and anti\u2010inflammatory cytokine releasing potential of<\/jats:italic> Brugia malayi <jats:italic>adult worm fractions and their role in filarial infection and pathogenesis. THP\u20101 cells were incubated with soluble somatic<\/jats:italic> Brugia malayi <jats:italic>adult worm extract (BmAS) and its Sephadex G\u2010200 fractions BmAFI, BmAFII and BmAFIII and the effect of the fractions on parasitological, immunological and lymph node parameters was assessed in<\/jats:italic> Mastomys coucha. <jats:italic>BmAFII stimulated the pro\u2010inflammatory TNF\u2010\u03b1, IL\u20101\u03b2 and IL\u20106 release; IL\u201010 release was insignificant. Sensitization of animals with BmAFII and subsequent intraperitoneal implantation of worms enhanced CMI response. BmAFII also increased lymph node weight and cellularity, stimulated lymph node mast cells and eliminated intraperitoneally instilled worms. BmAFI stimulated several folds more release of IL\u201010, whereas TNF\u2010\u03b1 release was negligible. Sensitization with BmAFI elicited low CMI responses, moderately stimulated mast cells and facilitated survival of implanted adult parasites. Fifty percent of naive animals exposed to BmAFI showed oedematous lymph nodes and increased node weight. NCP\u2010bound molecules corresponding to BmAFI and II showed cytokine\u2010stimulating potential<\/jats:italic> in vitro<jats:italic>. It is concluded that BmAFII is protective and stimulates pro\u2010inflammatory cytokines, whereas BmAFI facilitates parasite survival and stimulates IL\u201010.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.0141-9838.2004.00725.x","type":"journal-article","created":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T10:22:57Z","timestamp":1109931777000},"page":"397-407","source":"Crossref","is-referenced-by-count":22,"title":["Inflammatory antigens of <i>Brugia malayi<\/i> and their effect on rodent host <i>Mastomys coucha<\/i>"],"prefix":"10.1111","volume":"26","author":[{"given":"S.","family":"Dixit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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