{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:57:58Z","timestamp":1777517878992,"version":"3.51.4"},"reference-count":99,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2005,3,15]],"date-time":"2005-03-15T00:00:00Z","timestamp":1110844800000},"content-version":"vor","delay-in-days":134,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p><jats:italic>Advances in hookworm immunoepidemiology are reviewed. Recent studies demonstrate a mixed Th1\/Th2 response in human hookworm infection, with immunosuppression of specific and nonspecific IFN\u2010\u03b3 responses. There is increasing evidence for protective immunity in human hookworm infection, including anti\u2010larval IL\u20105\u2010 and IgE\u2010dependent mechanisms, and for immunological interactions between hookworm infection and other diseases.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.0141-9838.2004.00727.x","type":"journal-article","created":{"date-parts":[[2005,3,15]],"date-time":"2005-03-15T18:59:59Z","timestamp":1110913199000},"page":"443-454","source":"Crossref","is-referenced-by-count":52,"title":["The immunoepidemiology of human hookworm infection"],"prefix":"10.1111","volume":"26","author":[{"given":"R. J.","family":"Quinnell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bethony","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. I.","family":"Pritchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3,15]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2003.10.002"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(97)01144-7"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032492"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(04)58004-1"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000058666"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60552-7"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(03)00158-9"},{"key":"e_1_2_10_9_2","unstructured":"BethonyJ LoukasA SmoutM et al.Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals.Lancet in press."},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.296.5567.490"},{"key":"e_1_2_10_11_2","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1080\/00365540110026656","article-title":"human immunodeficiency virus and tuberculosis","volume":"33","author":"Borkow G","year":"2001","journal-title":"Scand J Infect Dis"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-004-0003-3"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/15169"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(87)90060-3"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.689-703.2001"},{"key":"e_1_2_10_16_2","first-page":"93","volume-title":"Human Parasitic Diseases: Hookworm Infections.","author":"Behnke JM.","year":"1991"},{"key":"e_1_2_10_17_2","first-page":"404","volume-title":"Hookworm Disease: Current Status and New Directions.","author":"Ottesen EA.","year":"1991"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1987.37.126"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(69)90011-X"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(78)90303-6"},{"key":"e_1_2_10_21_2","first-page":"38","article-title":"haematological and immunological findings","volume":"38","author":"Carroll SM","year":"1986","journal-title":"Trop Geogr Med"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1992.tb00034.x"},{"key":"e_1_2_10_23_2","first-page":"381","article-title":"IgG4 responses to antigens of adult Necator americanus: Potential for use in large\u2010scale epidemiological studies","volume":"74","author":"Palmer DR","year":"1996","journal-title":"Bull World Health Organ"},{"key":"e_1_2_10_24_2","doi-asserted-by":"crossref","first-page":"672","DOI":"10.4269\/ajtmh.1996.54.672","article-title":"Immunoglobulin G subclass antibodies against excretory\/secretory antigens of Ancylostoma caninum in human enteric infections","volume":"54","author":"Loukas A","year":"1996","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(91)90239-U"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1017\/S095026880005264X"},{"key":"e_1_2_10_27_2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1128\/jcm.26.4.739-742.1988","article-title":"Role of specific immunoglobulin E to excretory\u2013secretory antigen in diagnosis and prognosis of hookworm infection","volume":"26","author":"Ganguly NK","year":"1988","journal-title":"J Clin Microbiol"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1995.tb01005.x"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1974.tb01388.x"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1972.21.913"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1993.tb00601.x"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1993.tb00571.x"},{"key":"e_1_2_10_33_2","first-page":"531","article-title":"Serum and intestinal immunoglobulins in patients of ancylostomiasis","volume":"71","author":"Kumar N","year":"1980","journal-title":"Indian J Med Res"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/154.5.778"},{"key":"e_1_2_10_35_2","first-page":"89","article-title":"Antigen\u2010induced lymphocyte blastogenesis in a hookworm (Necator americanus) infection in man","volume":"27","author":"Taylor MM","year":"1976","journal-title":"Tropenmed Parasitol"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004360100419"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00477.x"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02449.x"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1086\/422256"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1086\/339005"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1086\/315830"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.11.6447"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2001.00366.x"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1999.00238.x"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0001-706X(95)00084-R"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(95)80169-3"},{"key":"e_1_2_10_47_2","doi-asserted-by":"crossref","first-page":"10008","DOI":"10.1016\/S0021-9258(17)36982-X","article-title":"A hookworm glycoprotein that inhibits neutrophil function is a ligand of the integrin CD11b\/CD18","volume":"269","author":"Moyle M","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_10_48_2","first-page":"21","article-title":"The human hookworm pathogen Necator americanus induces apoptosis in T lymphocytes","volume":"22","author":"Chow SC","year":"2000","journal-title":"Parasite Immunol"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1183"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1992.tb00029.x"},{"key":"e_1_2_10_51_2","unstructured":"WalshEA.PhD.Thesis University of Nottingham 1994."},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000061333"},{"key":"e_1_2_10_53_2","first-page":"565","article-title":"Fall in IgE levels after treatment for hookworm","volume":"18","author":"Grove DI","year":"1974","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_10_54_2","first-page":"545","article-title":"Serum IgE concentrations in relation to antihelminthic treatment in a Javanese population with hookworm","volume":"13","author":"Biroum\u2010Noerjasin.","year":"1973","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_10_55_2","first-page":"221","article-title":"Immunosuppression in Nigerians with hookworm infection","volume":"23","author":"Olatunde BO","year":"1994","journal-title":"Afr J Med Med Sci"},{"key":"e_1_2_10_56_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1385\/CRIAI:26:1:61","article-title":"The innate allergenicity of helminth parasites","volume":"26","author":"Falcone FH","year":"2004","journal-title":"Clin Rev Allergy Immunol"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.4.2699"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.6.1380"},{"key":"e_1_2_10_59_2","article-title":"The assessment of hookworm calreticulin as a potential vaccine for necatoriasis","author":"Beard J","year":"2005","journal-title":"Parasite Immunol"},{"key":"e_1_2_10_60_2","first-page":"147","volume-title":"Hookworm Disease: Current Status and New Directions.","author":"Bundy DAP.","year":"1991"},{"key":"e_1_2_10_61_2","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198545996.001.0001","volume-title":"Infectious Diseases of Humans. Dynamics and Control","author":"Anderson RM","year":"1991"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/315493a0"},{"key":"e_1_2_10_63_2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1051\/parasite\/1952271237","article-title":"Deductions cliniques tirees de cinquante cas d\u2019ankylostomose provoquee","volume":"27","author":"Brumpt LC.","year":"1952","journal-title":"Ann Parasitol Hum Comp"},{"key":"e_1_2_10_64_2","first-page":"18","article-title":"Immunity to Necator americanus infection","volume":"31","author":"Beaver PC.","year":"1945","journal-title":"J Parasitol"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(03)00175-9"},{"key":"e_1_2_10_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(98)01318-0"},{"key":"e_1_2_10_67_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2001.00383.x"},{"key":"e_1_2_10_68_2","doi-asserted-by":"publisher","DOI":"10.1086\/319867"},{"key":"e_1_2_10_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1995.tb00968.x"},{"key":"e_1_2_10_70_2","first-page":"19","article-title":"by the use of the dilution egg count method","volume":"6","author":"Hill RB.","year":"1926","journal-title":"Am J Hyg"},{"key":"e_1_2_10_71_2","unstructured":"QuinnellRJ.D.Phil Thesis University of Oxford 1990."},{"key":"e_1_2_10_72_2","first-page":"201","article-title":"Quantitative genetic analysis of susceptibility to hookworm infection in a population from rural Zimbabwe","volume":"69","author":"Williams\u2010Blangero S","year":"1997","journal-title":"Hum Biol"},{"key":"e_1_2_10_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(01)90138-5"},{"key":"e_1_2_10_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1995.tb00897.x"},{"key":"e_1_2_10_75_2","doi-asserted-by":"publisher","DOI":"10.1111\/pim.1993.15.10.583"},{"key":"e_1_2_10_76_2","doi-asserted-by":"publisher","DOI":"10.1086\/425014"},{"key":"e_1_2_10_77_2","doi-asserted-by":"publisher","DOI":"10.1086\/422262"},{"key":"e_1_2_10_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(02)00248-5"},{"key":"e_1_2_10_79_2","doi-asserted-by":"publisher","DOI":"10.1086\/315059"},{"key":"e_1_2_10_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00371-0"},{"key":"e_1_2_10_81_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000074953"},{"key":"e_1_2_10_82_2","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2001)087[0619:IOACBP]2.0.CO;2"},{"key":"e_1_2_10_83_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1989.tb00667.x"},{"key":"e_1_2_10_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(88)90012-6"},{"key":"e_1_2_10_85_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.4.2203-2213.2004"},{"key":"e_1_2_10_86_2","first-page":"633","article-title":"Analysis of the mechanism of immunodepression following heterologous antigenic stimulation during concurrent infection with Nematospiroides dubius","volume":"51","author":"Pritchard DI","year":"1984","journal-title":"Immunology"},{"key":"e_1_2_10_87_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X0000804X"},{"key":"e_1_2_10_88_2","doi-asserted-by":"publisher","DOI":"10.1086\/315837"},{"key":"e_1_2_10_89_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182001007272"},{"key":"e_1_2_10_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(02)00135-3"},{"key":"e_1_2_10_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(86)90301-9"},{"key":"e_1_2_10_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(99)90281-X"},{"key":"e_1_2_10_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(02)00108-0"},{"key":"e_1_2_10_94_2","doi-asserted-by":"publisher","DOI":"10.1086\/317627"},{"key":"e_1_2_10_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)03290-0"},{"key":"e_1_2_10_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(02)90229-4"},{"key":"e_1_2_10_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(03)90094-0"},{"key":"e_1_2_10_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06579-5"},{"key":"e_1_2_10_99_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.pt.2005.02.002","article-title":"Parasite role reversal: worms on trial","author":"Falcone FH.&","year":"2005","journal-title":"Trends Parasitol"},{"key":"e_1_2_10_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(78)90078-4"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0141-9838.2004.00727.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0141-9838.2004.00727.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T02:35:35Z","timestamp":1706063735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0141-9838.2004.00727.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":99,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1111\/j.0141-9838.2004.00727.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0141-9838.2004.00727.x","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}