{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:42:00Z","timestamp":1780472520954,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,1,30]],"date-time":"2007-01-30T00:00:00Z","timestamp":1170115200000},"content-version":"vor","delay-in-days":516,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Preventive Cardiology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p> <jats:bold>\n            <jats:italic>Statins are administered daily, but because of their long half\u2010lives, atorvastatin and rosuvastatin can be given every other day (q.o.d.). We examined the effect of q.o.d. statin therapy in 25 patients treated with either atorvastatin (mean dose, 18.8 mg q.o.d.) or rosuvastatin (mean dose, 9.7 mg q.o.d.). Low\u2010density lipoprotein cholesterol decreased 43%, triglycerides (mean \u00b1 SEM) decreased 22%\u00b16%, and high\u2010density lipoprotein cholesterol increased 9%\u00b16% with q.o.d. atorvastatin (n=9; p&lt;0.05 for all). Low\u2010density lipoprotein cholesterol decreased 28%, triglycerides decreased 15%\u00b16%, and high\u2010density lipoprotein cholesterol increased 10%\u00b15% with rosuvastatin q.o.d. (n=16; p&lt;0.05 for all). We conclude that q.o.d. treatment with long\u2010acting statins significantly improves serum lipid levels.<\/jats:italic>\n          <\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.0197-3118.2005.04404.x","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T18:20:36Z","timestamp":1170440436000},"page":"197-199","source":"Crossref","is-referenced-by-count":29,"title":["Decreasing LDL Cholesterol and Medication Cost With Every\u2010Other\u2010Day Statin Therapy"],"prefix":"10.1111","volume":"8","author":[{"given":"Monika A.","family":"Juszczyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Seip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,30]]},"reference":[{"issue":"8934","key":"e_1_2_5_2_2","first-page":"1383","article-title":"Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)","volume":"344","year":"1994","journal-title":"Lancet"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811053391902"},{"issue":"9326","key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0140-6736(02)09327-3","article-title":"MRC\/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high\u2010risk individuals: a randomised, placebo\u2010controlled trial","volume":"360","author":"Heart Protection Study Collaborative Group","year":"2002","journal-title":"Lancet"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.13.1681"},{"key":"e_1_2_5_6_2","first-page":"A1","article-title":"An FDA shift could transform market for statins: agency will consider allowing over\u2010the\u2010counter sales of cholesterol medicine","author":"Wilde MA","year":"2003","journal-title":"Wall Street Journal"},{"key":"e_1_2_5_7_2","unstructured":"Crestor ripple likely minor statin costs on rise experts say"},{"key":"e_1_2_5_8_2","article-title":"Potent therapy lowers heart death","author":"Sternberg S","year":"2004","journal-title":"USA Today"},{"key":"e_1_2_5_9_2","volume-title":"Lipitor (atorvastatin calcium) tablet [product information]","year":"1999"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199753050-00011"},{"key":"e_1_2_5_11_2","volume-title":"Crestor (rosuvastatin calcium) [package insert]","year":"2003"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(96)90218-0"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(02)00140-0"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/107424840300800205"}],"container-title":["Preventive Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0197-3118.2005.04404.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0197-3118.2005.04404.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/j.0197-3118.2005.04404.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0197-3118.2005.04404.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T14:21:06Z","timestamp":1694355666000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0197-3118.2005.04404.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1111\/j.0197-3118.2005.04404.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0197-3118.2005.04404.x","archive":["Portico"],"relation":{},"ISSN":["1520-037X","1751-7141"],"issn-type":[{"value":"1520-037X","type":"print"},{"value":"1751-7141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}