{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:36:40Z","timestamp":1790836600276,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T00:00:00Z","timestamp":1170806400000},"content-version":"vor","delay-in-days":402,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cardiometabolic Synd"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p> <jats:italic>The regulation of blood glucose levels involves a finely tuned relationship between insulin sensitivity, hepatic glucose output, and production of insulin. The cardiometabolic syndrome includes in its definition criteria a disturbance of normal glucose tolerance and implies development of both insulin resistance and \u03b2\u2010cell dysfunction. There is now abundant evidence pointing toward a central role of dysregulation of the \u03b2\u2010cell function and mass in the development of impaired glucose tolerance. Mechanisms implicated in \u03b2\u2010cell dysfunction include genetic abnormalities, prenatal and early postnatal insults, and environmental events along with obesity, dyslipidemia\u2010lipotoxicity, glucotoxicity, oxidative stress, chronic low\u2010grade inflammation, amyloid deposition, and activation of the local renin\u2014angiotensin system. Novel therapeutic characteristics of known medications such as metformin, thiazolidinediones, angiotensin\u2010converting enzyme inhibitors\/angiotensin receptor blockers, and novel medications such as exendin\u20104 promise encouraging possibilities to battle against the cardiometabolic syndrome and the future development of cardiovascular disease.<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.0197-3118.2006.05458.x","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T15:06:08Z","timestamp":1170860768000},"page":"41-46","source":"Crossref","is-referenced-by-count":30,"title":["The Role of \u03b2\u2010Cell Dysfunction in the Cardiometabolic Syndrome"],"prefix":"10.1111","volume":"1","author":[{"given":"Guido","family":"Lastra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Margarita","family":"Manrique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin R.","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,7]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.22.2644"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.2007.S265"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07786.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2004.00361.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.11.2740"},{"key":"e_1_2_7_7_2","first-page":"247","article-title":"The key role of islet dysfunction in type II diabetes mellitus","volume":"18","author":"Porte D","year":"1995","journal-title":"Clin Invest Med"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81896-6"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.51.30253"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117715"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.45.4.422"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00053.2003"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505695200"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1977.tb12486.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.4.1271"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.2.385"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/153537020322800102"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/146642400512500211"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200423586"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2401"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104343"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.1.273"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.19.10857"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.3.581"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.48.30261"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.4.803"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.8.3422"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.5.735"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.2007.S119"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(00)80021-9"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.11.2481"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.4.738"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.1.102"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200215318"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.8.1683"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.suppl_2.S108"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122686299"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0395"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305683101"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300102200"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0197-3118.2006.05454.x"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0446"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.42.7"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103160"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.8.2404"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.9.2796"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.11.2844"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0079"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1787-2"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2005.03.002"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.3.734"}],"container-title":["Journal of the CardioMetabolic Syndrome"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0197-3118.2006.05458.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T14:16:31Z","timestamp":1697465791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0197-3118.2006.05458.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1111\/j.0197-3118.2006.05458.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0197-3118.2006.05458.x","archive":["Portico"],"relation":{},"ISSN":["1559-4564","1559-4572"],"issn-type":[{"value":"1559-4564","type":"print"},{"value":"1559-4572","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}