{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:08:20Z","timestamp":1760170100499},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,3,18]],"date-time":"2004-03-18T00:00:00Z","timestamp":1079568000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent studies suggest that peripheral morphine may represent a valuable treatment in acute inflammatory painful diseases through peripheral or central mechanisms. In the present study, anti\u2010inflammatory effects of systemic morphine on carrageenan\u2010induced hind paw oedema were examined in a model of peripheral acute oedema in mice. Carrageenan induced a time\u2010dependent inflammation that was maximal 3\u2003h after administration. While intraperitoneal administration of morphine sulfate at a low dose (1\u2003mg\/kg) increased carrageenan\u2010induced hind paw oedema, intraperitoneal injection of morphine sulfate at a high dose (7\u2003mg\/kg) resulted in significant anti\u2010inflammatory effects on carrageenan\u2010induced hind paw oedema. These anti\u2010inflammatory effects were blocked by pretreatment with naloxone. Measuring the serum levels of interleukin\u20101\u03b2 revealed that increases in serum levels of this cytokine were involved in morphine anti\u2010inflammatory effects. Pretreatment with naloxone decreased interleukin\u20101\u03b2 serum levels near to those of control group. In conclusion, these data demonstrate that morphine produced pro\u2010 or anti\u2010inflammatory effects in a dose\u2010dependent manner through peripheral or central mechanisms. The observed anti\u2010inflammatory effects may be due to an increase in the cytokine production and\/or release by host immune systems.<\/jats:p>","DOI":"10.1111\/j.0300-9475.2004.01396.x","type":"journal-article","created":{"date-parts":[[2004,3,18]],"date-time":"2004-03-18T14:18:02Z","timestamp":1079619482000},"page":"273-277","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Involvement of Interleukin\u20101\u03b2 in Systemic Morphine Effects on Paw Oedema in a Mouse Model of Acute Inflammation"],"prefix":"10.1111","volume":"59","author":[{"given":"Z.","family":"Pourpak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ahmadiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Alebouyeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.15.5935"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15601.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00323-7"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02342227"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00871-7"},{"key":"e_1_2_6_7_2","first-page":"1068","article-title":"Peripheral effects of opioids in a model of chronic intestinal inflammation in mice","volume":"287","author":"Puig MM","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(90)90054-H"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00110-4"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2002.1947"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90042-J"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90201-4"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8719(00)00089-7"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00175-4"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(99)00216-7"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00440-2"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00186-7"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000063800"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-5347-2_8"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(98)01241-3"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199804)41:4<634::AID-ART10>3.0.CO;2-1"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02023-0"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(00)00209-5"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00106-S"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.10.4219"},{"key":"e_1_2_6_26_2","first-page":"619","volume-title":"Goodman and Gillmans. The Pharmacological Basis of Therapeutics","author":"Schimmer BP","year":"1996"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0300-9475.2004.01396.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0300-9475.2004.01396.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T08:42:58Z","timestamp":1697272978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0300-9475.2004.01396.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["10.1111\/j.0300-9475.2004.01396.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0300-9475.2004.01396.x","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3]]},"assertion":[{"value":"2004-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}