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Effects of therapeutic immunization against <jats:italic>H. pylori<\/jats:italic> infection on the Treg function were also studied to better understand the mechanisms leading to postimmunization gastritis in these mice. Depletion of Treg led to extensive proliferation to <jats:italic>H. pylori<\/jats:italic> antigens of CD4<jats:sup>+<\/jats:sup> T cells isolated from either na\u00efve, <jats:italic>H. pylori<\/jats:italic>\u2010infected or <jats:italic>H. pylori<\/jats:italic>\u2010immunized mice. Using the Treg\u2010depleted CD4<jats:sup>+<\/jats:sup> T cells from immunized mice as effector cells, we compared the suppressive efficacy of Treg isolated from na\u00efve, infected or immunized mice and found that Treg from na\u00efve mice, and slightly less efficiently from infected mice, suppressed the CD25<jats:sup>\u2013<\/jats:sup> effector T\u2010cell response and in most cases were distinctly more efficacious than Treg isolated from immunized mice. The suppressive efficacy of Treg isolated from the differently treated mice correlated closely with production of interleukin\u20105 (IL\u20105) by the Treg and suppression of interferon\u2010\u03b3 and IL\u20102 production by the CD25<jats:sup>\u2013<\/jats:sup> effector T cells. Our study is the first to demonstrate in <jats:italic>H. pylori<\/jats:italic>\u2010induced chronic infection, antigen\u2010specific Treg with differential efficacy in suppressing <jats:italic>H. pylori<\/jats:italic> proinflammatory T effector cells.<\/jats:p>","DOI":"10.1111\/j.0300-9475.2004.01447.x","type":"journal-article","created":{"date-parts":[[2004,7,5]],"date-time":"2004-07-05T19:20:35Z","timestamp":1089055235000},"page":"82-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Antigen\u2010Specific <i>In Vitro<\/i> Suppression of Murine <i>Helicobacter pylori<\/i>\u2010Reactive Immunopathological T Cells by CD4<sup>+<\/sup>CD25<sup>+<\/sup> Regulatory T 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