{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:18:51Z","timestamp":1697001531118},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,8,20]],"date-time":"2004-08-20T00:00:00Z","timestamp":1092960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This investigation was planned to assess the therapeutic efficacy of glucuronoxylomannan (GXM) in collagen\u2010induced arthritis (CIA). GXM was isolated from culture filtrate of <jats:italic>Cryptococcus neoformans<\/jats:italic> var. gattii, serotype C. CIA was induced by the immunization of Dark Agouti rats with bovine type II collagen in incomplete Freund's adjuvant. GXM solution at two doses, 25 and 50\u2003mg\/kg, was administered intraperitoneally. Onset of i.p. injections of GXM to prevention and treatment groups was days 0 and 10 postimmunization, respectively. The WEHI\u2010164 cell line was used for assaying tolerability, matrix metalloproteinase type 2 (MMP\u20102) activity and apoptosis. MMP\u20102 activity was assessed using zymography. For assessment of apoptosis, the terminal deoxyribonucleotidyl transferase\u2010mediated dUTP nick\u2010end labelling method was used. The results of this experiment showed that the treatment of CIA with GXM at a dose of 50\u2003mg\/kg could suppress disease development both prophylactically and therapeutically. This beneficial effect of GXM was associated with a significant decrease in the anti\u2010CII antibody response compared with untreated rats. Moreover, GXM therapy could diminish MMP\u20102 activity, but it had no notable effect on apoptosis. GXM also showed a high tolerability compared with certain steroidal and non\u2010steroidal anti\u2010inflammatory drugs. We conclude that GXM suppresses the development of disease in CIA and it could be recommended as a new immunosuppressive and anti\u2010inflammatory agent for further investigations.<\/jats:p>","DOI":"10.1111\/j.0300-9475.2004.01458.x","type":"journal-article","created":{"date-parts":[[2004,8,20]],"date-time":"2004-08-20T16:11:05Z","timestamp":1093018265000},"page":"226-232","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tolerability and Anti\u2010Inflammatory Effects of Glucuronoxylomannan in Collagen\u2010Induced Arthritis"],"prefix":"10.1111","volume":"60","author":[{"given":"A.","family":"Mirshafiey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. T.","family":"Ngoc Dzung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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