{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T13:35:07Z","timestamp":1715952907978},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,8,20]],"date-time":"2004-08-20T00:00:00Z","timestamp":1092960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In search for a possible explanation of the phenotypic heterogeneity in selective immunoglobulin (Ig)A deficiency, we studied the IgG2 antibody response to meningococcal polysaccharide A (PSA) in IgA\u2010deficient (IgAd) individuals after vaccination with meningococcal A\u2003+\u2003C polysaccharide vaccine. Two groups of IgAd individuals, one frequently infected and one clinically apparently healthy, as well as healthy controls, were studied. In response to meningococcal A\u2003+\u2003C polysaccharide vaccine, a significant titre increase of specific IgG2 anti\u2010PSA was found in 71% of the control individuals, in 50% of the healthy and in 42% of the infection\u2010prone IgAd individuals. The specific IgG2 response against meningococcal PSA was significantly lower in the infection\u2010prone IgAd individuals compared to the controls (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Among the IgAd individuals who responded with a significant IgG2 antibody increase, the IgG2 antibody response was significantly lower in the infection\u2010prone than in the healthy IgAd individuals (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Thus, a limited capacity to mount a specific IgG2 response may suggest a more profound antibody maturation defect in infection\u2010prone IgAd patients compared to healthy IgAd individuals.<\/jats:p>","DOI":"10.1111\/j.0300-9475.2004.01459.x","type":"journal-article","created":{"date-parts":[[2004,8,20]],"date-time":"2004-08-20T16:11:05Z","timestamp":1093018265000},"page":"292-298","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Aberrant IgG2 Antibody Response to Neisseria Meningitidis Polysaccharide A After Vaccination in Frequently Infected Compared to Healthy IgA\u2010Deficient Individuals"],"prefix":"10.1111","volume":"60","author":[{"given":"V.","family":"Friman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hahn\u2010Zoric","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bj\u00f6rkander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.\u2010A.","family":"Oxelius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. \u00c5.","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197105000-00004"},{"key":"e_1_2_6_3_2","first-page":"62","volume-title":"Primary and Secondary Immunodeficiency 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