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As measured by Western blotting, the levels of PKC\u03b2, \u03b4, \u03b7, \u03b5, \u03b8 and \u03b6 (but not of PKC\u03b1) significantly decreased in T cells of SLE patients. In monocytes, however, we observed marked suppressions only in the expressions of PKC\u03b4, \u03b5 and \u03b6 but not in the expressions of other PKC isoforms. <jats:italic>In vivo<\/jats:italic> corticosteroid application, as well as <jats:italic>in vitro<\/jats:italic> steroid treatment of monocytes, elevated the expressions of most isoforms close to normal values; however, the decreased levels of PKC\u03b8 and \u03b6 were not affected by steroid application. These alterations were characteristic to SLE because we could not detect any changes in the PKC levels in mononuclear cells of primary Sj\u00f6gren's syndrome and mixed connective tissue disease patients. These results suggest that impaired PKC isoenzyme pattern may exist in the T cells and monocytes of SLE patients. Furthermore, the clinically efficient glucocorticoid application in SLE can increase the expression of some members of PKC system.<\/jats:p>","DOI":"10.1111\/j.0300-9475.2004.01485.x","type":"journal-article","created":{"date-parts":[[2004,9,20]],"date-time":"2004-09-20T14:26:50Z","timestamp":1095690410000},"page":"421-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Abnormal Cell\u2010Specific Expressions of Certain Protein Kinase C Isoenzymes in Peripheral Mononuclear Cells of Patients with Systemic Lupus Erythematosus: Effect of Corticosteroid 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