{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:23:35Z","timestamp":1760887415373},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,2,10]],"date-time":"2004-02-10T00:00:00Z","timestamp":1076371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Backgrounds, aims: <\/jats:bold> The aim of our study was to evaluate the clinical, radiological and microbiological response to the local delivery of tetracycline (TE) of sites with persistent periodontal lesions.<\/jats:p><jats:p><jats:bold>Material and Methods: <\/jats:bold> The study was conducted in a split\u2010mouth design. Nineteen patients with at least four bilateral pockets 4\u20135\u2003mm and bleeding on probing (BOP) were treated with scaling and root planing (SRP) plus TE fibres (test sites) or with SRP alone (control sites). Clinical and radiological measurements were taken at baseline, 6 months and 12 months post\u2010operatively. Subgingival plaque samples were collected at baseline, at fibres removal, 6 and 12 months following treatment and analysed by polymerase chain reaction.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Both treatments yielded a statistically significant (<jats:italic>p<\/jats:italic>&lt;0.05) reduction of probing depth (2.05 and 1.21\u2003mm), gain of clinical attachment level (1.71 and 0.53\u2003mm) and reduction of BOP scores (23.68% and 57.89%) for TE and SRP groups, respectively, when comparing 12\u2010month data with baseline. The differences between two groups were significant. The prevalence of <jats:italic>Treponema denticola<\/jats:italic> and <jats:italic>Bacteroides forsythus<\/jats:italic> decreased after therapy in both groups but only in the test sites <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic> and <jats:italic>Prevotella intermedia<\/jats:italic> were not yield detected. The pathogens could be eliminated from five periodontal pockets by SRP alone, while 21 TE sites were not recolonized at 12 months.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> SRP plus TE fibres gave the greatest advantage in the treatment of periodontal persistent lesions at least 12 months following treatment.<\/jats:p>","DOI":"10.1111\/j.0303-6979.2004.00457.x","type":"journal-article","created":{"date-parts":[[2004,2,10]],"date-time":"2004-02-10T10:32:37Z","timestamp":1076409157000},"page":"166-172","source":"Crossref","is-referenced-by-count":39,"title":["Debridement and local application of tetracycline\u2010loaded fibres in the management of persistent periodontitis: results after 12 months"],"prefix":"10.1111","volume":"31","author":[{"given":"M.","family":"Aimetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Torta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Cirillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Caposio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Romagnoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb00285.x"},{"key":"e_1_2_6_3_1","first-page":"121","article-title":"Molecular approaches to the identification and treatment monitoring of periodontal pathogens","volume":"26","author":"Caposio P.","year":"2003","journal-title":"New Microbiologica"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027012897.x"},{"issue":"2","key":"e_1_2_6_5_1","first-page":"6","article-title":"Clinical significance of non\u2010surgical periodontal therapy: an evidence\u2010based perspective of scaling and root planing","volume":"29","author":"Cobb C. 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