{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T21:22:04Z","timestamp":1794345724677,"version":"4.9.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,3,9]],"date-time":"2004-03-09T00:00:00Z","timestamp":1078790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Controlled\u2010release delivery systems enable the clinician to extend the half\u2010life period of locally administered antibiotics in gingival crevicular fluid (GCF) significantly. The aim of this split\u2010mouth study was to compare the pharmacokinetic profile of two different doxycycline gels (DOXY and ATRI) for topical subgingival application. Pharmacokinetics of both doxycycline gels were analyzed in GCF and saliva.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In 10 patients suffering from severe periodontitis, 10 pairs of contralateral defects (pocket depth 5\u2003mm\/bleeding on probing or 6\u2003mm) were randomly assigned either to the first application of DOXY or ATRI. Fourteen days after the topical application of the first antibiotic gel, the application of the second gel in the contralateral defect took place. Clinical examinations at baseline showed no significant differences between sites treated with DOXY and ATRI. Samples of GCF and saliva were drawn baseline, 2, 5 and 24\u2003h after application, 2, 3, 4, 7, 9 and 11 days after application. Separation and quantitative measurement of both doxycycline\u2010gels was performed with HPLC\u2010 and UV\u2010detection at <jats:italic>\u03bb<\/jats:italic>=260\u2003nm.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In saliva specimens, time\u2010dependent changes of mean doxycycline concentration were almost identical for both doxycycline\u2010gels and declined from a maximum 2\u2003h after application (ATRI: 6653.90\u00b13096.14\u2003<jats:italic>\u03bc<\/jats:italic>g\/ml; DOXY: 5386.60\u00b11542.02\u2003<jats:italic>\u03bc<\/jats:italic>g\/ml [arithmetic mean\u00b1SEM]) to zero values 9 days after application. In crevicular fluid specimens, sites treated with ATRI exhibited a faster decrease of mean doxycycline concentration (1085.30, 264.00, 273.94, and 258.00\u2003<jats:italic>\u03bc<\/jats:italic>g\/ml measured 2, 5, 24, and 48\u2003h after application) than sites treated with DOXY (1388.38, 1300.40, 803.73, and 235.10\u2003<jats:italic>\u03bc<\/jats:italic>g\/ml). The faster decrease of ATRI compared with DOXY could not be proved to be statistically significantly different.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Both doxycycline gels showed pharmacokinetics of controlled\u2010release delivery systems.<\/jats:p>","DOI":"10.1111\/j.0303-6979.2004.00494.x","type":"journal-article","created":{"date-parts":[[2004,3,9]],"date-time":"2004-03-09T12:43:04Z","timestamp":1078836184000},"page":"286-292","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of the pharmacokinetic profiles of two locally administered doxycycline gels in crevicular fluid and saliva"],"prefix":"10.1111","volume":"31","author":[{"given":"Ti\u2010Sun","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homa","family":"Klimpel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Fiehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Eickholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,3,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0267-6605(89)90034-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.7.1347"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1993.tb04345.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1139\/m92-071"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.491"},{"key":"e_1_2_6_7_1","first-page":"289","article-title":"Antibiotika und parodontalpathogene Bakteriesspezies im Biofilm \u2013 eine In\u2010vitro\u2010Studie","volume":"57","author":"Eick S.","year":"2002","journal-title":"Dtsch Zahn\u00e4rztl Z"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290204.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1902\/jop.1999.70.5.490","article-title":"Two multi\u2010center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planing in the treatment of periodontitis","volume":"70","author":"Garrett S.","year":"1999","journal-title":"Journal of Periodontology"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1983.54.10.575"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.5.507"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1979.tb01924.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01308.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.11.1285"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.7.819"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1967.38.6.610"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.2.113"},{"key":"e_1_2_6_18_1","first-page":"38","volume-title":"Proceedings of the Second European Workshop on Periodontology. 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