{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:45:29Z","timestamp":1773409529339,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,7,15]],"date-time":"2004-07-15T00:00:00Z","timestamp":1089849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives: <\/jats:bold> The purpose of this study was to evaluate the effect of subgingival administration of doxycycline as an adjunct to periodontal therapy in type 1 diabetes mellitus (DM) patients.<\/jats:p><jats:p><jats:bold>Material and methods: <\/jats:bold> Twenty\u2010two paired periodontal defects 5.0\u2003mm were treated in 11 patients (35\u201355 years old). After initial therapy the sites were randomly assigned into test (scaling and root planing+subgingival administration of 10% doxycycline hyclate gel) or control (scaling and root planing+subgingival placebo gel) groups. The clinical parameters of clinical attachment level (CAL), probing depth (PD) and gingival margin level (GML) for recession determination were assessed at baseline, after 6 weeks, and 6, 9 and 12 months, using a computerized probe. Data were statistically evaluated using Duncan and <jats:italic>F<\/jats:italic> tests.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Between study group comparisons indicated PD reduction and CAL gain were greater in the test group than in the control group at 6 weeks and 6, 9 and 12 months but only statistically significant at 12 months (<jats:italic>p<\/jats:italic>&lt;0.05). Within study group comparisons indicated statistically significant differences were found for CAL and PD values favouring the adjunctive doxycycline group from baseline to 6 weeks and 6, 9 and 12 months (<jats:italic>p<\/jats:italic>&lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> These findings suggest that subgingivally delivered doxycycline hyclate produces additional favorable clinical results to periodontal therapy in type 1 DM patients.<\/jats:p>","DOI":"10.1111\/j.0303-6979.2004.00576.x","type":"journal-article","created":{"date-parts":[[2004,7,15]],"date-time":"2004-07-15T09:56:32Z","timestamp":1089885392000},"page":"648-653","source":"Crossref","is-referenced-by-count":35,"title":["Therapy with adjunctive doxycycline local delivery in patients with type 1 diabetes mellitus and periodontitis"],"prefix":"10.1111","volume":"31","author":[{"given":"Antonio Fernando","family":"Martorelli de Lima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cmila Cristina","family":"Cury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Bazan","family":"Palioto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adhemar Mendes","family":"Duro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Carvalho da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry F.","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb02535.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290404.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.4.664"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1988.59.12.816"},{"key":"e_1_2_6_6_1","first-page":"417","article-title":"In vitro study by fluorescence microscopy and microradiography of tetracycline\u2013tooth interaction","volume":"91","author":"Bjorvatn K.","year":"1983","journal-title":"Scandinavian Journal of Dental Research"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.6.836"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.4.521"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2001.280810.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02417.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374980120011501"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.10.849"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290204.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.1.30"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1982.tb01160.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1991.tb01626.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.1.22"},{"key":"e_1_2_6_18_1","first-page":"12","volume-title":"Periodontal Medicine","author":"Genco R. 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