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Within the area of altered collagen, there may be deposition of acellular substances such as mucin (blue) or fibrin (red), or there may be neutrophils with nuclear dust (blue), eosinophils (red), or flame figures (red). These color distinctions can be used as a simple algorithm for the diagnosis of collagenolytic granulomas, i.e. \u2018blue\u2019 granulomas vs. \u2018red\u2019 granulomas. Eight diagnoses are included within these two groupings, which are discussed in this two\u2010part article. In this first part, the clinical presentation, pathogenesis, and histologic features of the \u2018blue\u2019 collagenolytic granulomas are discussed. These are the lesions of granuloma annulare, Wegener's granulomatosis, and rheumatoid vasculitis. In the subsequent half of this two\u2010part series, the \u2018red\u2019 collagenolytic granulomas will be discussed; these are the lesions of necrobiosis lipoidica, necrobiotic xanthogranuloma, rheumatoid nodules, Churg\u2013Strauss syndrome, and eosinophilic cellulitis (Well's syndrome).<\/jats:p>","DOI":"10.1111\/j.0303-6987.2004.00194.x","type":"journal-article","created":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T13:22:04Z","timestamp":1080825724000},"page":"353-361","source":"Crossref","is-referenced-by-count":54,"title":["Collagenolytic (necrobiotic) granulomas: part 1 \u2013 the \u2018blue\u2019 granulomas"],"prefix":"10.1111","volume":"31","author":[{"given":"Jane M.","family":"Lynch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry L.","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,4]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198208000-00018"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00547.x"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002560050367"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90212-3"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(80)80181-2"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70316-9"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1991.tb00324.x"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.16.2043"},{"key":"e_1_2_9_10_2","first-page":"1647","article-title":"Papules on the hands. 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