{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T23:35:38Z","timestamp":1794440138635,"version":"4.9.1"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,6,7]],"date-time":"2004-06-07T00:00:00Z","timestamp":1086566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Cutaneous tumor metastasis may be the first manifestation of cancer, but more often is a harbinger of advanced disease that portends an ominous prognosis. All skin accessions over the past 10\u2003years from a large Veterans Administration (VA) hospital were reviewed.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Archived histories, glass slides, and the immunohistochemical battery (IHC), were assessed to determine diagnostic accuracy.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Of the 100,453 cases reviewed, there were a total of 77 cases (75 males and 2 females) of cutaneous metastasis from the lungs (28.6%), metastatic melanoma (18.2%), gastrointestinal tract (14.2%), genitourinary tract (10.4%), head and neck (9.1%), hematologic (5.2%), breast (5.2%), and miscellaneous (&lt;2%). Metastasis represented the first indication of an internal malignancy in 7.8% of cases. The cutaneous sites of involvement included the head and neck (28%), the trunk (40%), the extremities (18%), and multiple sites (14%). The age range was 38\u201383\u2003years, with a mean of 62\u2003years. The average time interval between diagnosis of internal malignancy and cutaneous presentation was 33\u2003months (range: &lt;1\u2003month\u221222\u2003years), and the average survival following diagnosis was 7.5\u2003months (range: &lt;1\u2003month\u22128\u2003years). In a cohort of subjects, a truncated immunohistochemical battery consisting of CK\u20107, CK\u201020, and S\u2010100 was consistent with the expected staining pattern of the primary source of cutaneous metastasis in 83.33% of the patients.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Excluding the potential for age and gender bias in this study conducted in a VA setting, cutaneous metastases represent an uncommon, deadly, and late\u2010developing occurrence in many patients. Compared with previous studies, lung carcinoma remains the most common of the cutaneous metastases, with a relative rise in the incidence of metastatic melanoma. The immunohistochemical battery of CK\u20107, CK\u201020, and S\u2010100 is a helpful adjunct in narrowing the differential diagnosis of the primary site of a large proportion of cutaneous metastases, particularly tumors with an epithelioid appearance such as carcinomas and melanomas.<\/jats:p>","DOI":"10.1111\/j.0303-6987.2004.00207.x","type":"journal-article","created":{"date-parts":[[2004,6,7]],"date-time":"2004-06-07T09:44:33Z","timestamp":1086601473000},"page":"419-430","source":"Crossref","is-referenced-by-count":255,"title":["Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal"],"prefix":"10.1111","volume":"31","author":[{"given":"Sadia","family":"Saeed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie A.","family":"Keehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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