{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T10:28:08Z","timestamp":1794652088745,"version":"4.9.1"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,10,15]],"date-time":"2004-10-15T00:00:00Z","timestamp":1097798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Carcinosarcoma is a biphasic tumor composed of malignant epithelial and mesenchymal elements. Although the tumors have been reported in different locations, they rarely occur in the skin and have not been reported in the skin of external genitalia.<\/jats:p><jats:p><jats:bold>Case report:\u2002<\/jats:bold> We present such a case in a 71\u2010year\u2010old Taiwanese man. He had had a long\u2010term indolent nodule on scrotal skin, but it enlarged rapidly in 2\u2003weeks. Wide excision of the tumor was performed.<\/jats:p><jats:p><jats:bold>Results and Discussion:\u2002<\/jats:bold> The pathologic examination revealed a sweat gland carcinosarcoma consisting of admixed mucin\u2010producing adenocarcinoma and solid spindle cell sarcoma. The two components exhibited contrasting immunohistochemical profiles with the epithelial component diffusely positive for epithelial markers and S\u2010100 protein, while the sarcomatous component positive for vimentin and smooth muscle actin but negative for epithelial markers and S\u2010100 protein. The immunoreactivity for S\u2010100 protein in the epithelial component supports sweat gland origin. The tumor behaved aggressively. Local recurrence and distant metastases to lungs and brain occurred 6\u2003months and 18\u2003months later. The patient died of the disease 20\u2003months after the initial diagnosis.<\/jats:p>","DOI":"10.1111\/j.0303-6987.2004.00255.x","type":"journal-article","created":{"date-parts":[[2004,10,15]],"date-time":"2004-10-15T10:19:54Z","timestamp":1097835594000},"page":"678-682","source":"Crossref","is-referenced-by-count":11,"title":["Primary sweat gland carcinosarcoma of the scrotal skin"],"prefix":"10.1111","volume":"31","author":[{"given":"Tzu\u2010Ping","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin\u2010Chen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Ji\u2010Sien","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George F.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,15]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"118","article-title":"Carcinosarcomas: current perspectives and an historical review of nosological concepts","volume":"10","author":"Wick MR","year":"1993","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199612000-00012"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.08219.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1983.tb00339.x"},{"key":"e_1_2_6_6_2","first-page":"461","article-title":"Carcinosarcomas of the skin \u2013 report of two cases","volume":"58","author":"Iakovides J","year":"1988","journal-title":"Arch Geschwulstforsch"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1993.tb00655.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1995.tb00200.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199708000-00008"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1981.tb01004.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1988.tb00512.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00330-0"},{"key":"e_1_2_6_13_2","first-page":"64","volume-title":"Atlas of tumor pathology","author":"Murphy GF","year":"1991"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70188-1"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1984.tb00393.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199810000-00017"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0303-6987.2004.00255.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0303-6987.2004.00255.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0303-6987.2004.00255.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:25:32Z","timestamp":1697430332000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0303-6987.2004.00255.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,15]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1111\/j.0303-6987.2004.00255.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0303-6987.2004.00255.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,15]]}}}