{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:25:41Z","timestamp":1788251141974,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,8]],"date-time":"2005-06-08T00:00:00Z","timestamp":1118188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold>Lentigo maligna (LM) can histologically simulate dysplastic nevus (DN). Partial biopsy of LM may lead to misdiagnosis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>One hundred and fourteen cases of LM and LM melanoma (LMM) were diagnosed at the Veterans Affairs Palo Alto Health Care System (1993\u20132002). Biopsy and excision specimens for 68<jats:italic>in situ<\/jats:italic>and 28 invasive melanomas were classified as having predominant classical LM features, predominant DN\u2010like morphology, or a mixed pattern.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>Biopsy specimens demonstrated a predominant classical pattern in 38% (25\/65) LM and 36% (10\/28) LMM, predominant DN\u2010like features in 43% (28\/65) LM and 25% (7\/28) LMM, and mixed pattern in 15% (10\/65) LM and 29% (8\/28) LMM. Most LM and LMM biopsies were partial. Significant DN\u2010like features were present in 51% LM and 57% LMM excision specimens. Median age was 72\u2003years for LM and 73\u2003years for LMM, mean lesion diameters were 1.3 and 1.7\u2003cm for LM and LMM, respectively, and 85% of LM and 75% of LMM cases were located on heavily sun\u2010exposed sites.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>Misdiagnosis of LM or LMM as DN could have devastating results. Large pigmented lesions on sun\u2010damaged skin in elderly individuals should warrant consideration of LM\/LMM diagnosis, even in the setting of DN\u2010like features histologically. Excisional biopsy may help to avoid misdiagnosis.<\/jats:p>","DOI":"10.1111\/j.0303-6987.2005.00355.x","type":"journal-article","created":{"date-parts":[[2005,6,8]],"date-time":"2005-06-08T08:06:16Z","timestamp":1118217976000},"page":"405-412","source":"Crossref","is-referenced-by-count":43,"title":["Histologic similarities between lentigo maligna and dysplastic nevus: importance of clinicopathologic distinction"],"prefix":"10.1111","volume":"32","author":[{"given":"Farinaz","family":"Farrahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara M.","family":"Egbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Swetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,8]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"39","article-title":"Lentigo maligna 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