{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:21:17Z","timestamp":1785874877553,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Lichen planopilaris (LPP) is the prototype of scarring alopecias that mainly target the infundibuloisthmic (bulge) region of hair follicle. Hair follicle stem cells have been shown to reside in the bulge.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We carried out this study to better define the possible pathogenetic role of the bulge in LPP. Thirty\u2010five cases of LPP were studied. Multiple serial sections of biopsy specimens stained with hematoxylin and eosin, periodic acid Schiff\u2010diastase, and Elastic van Gieson. The following immunostains were applied: CD3, CD4, CD8, CD1a, and Ki\u201067. Uninvolved follicles and normal scalp biopsy specimens served as normal controls.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> All cases showed a lichenoid lymphocytic infiltrate at the bulge region. The bulb area was spared. CD8<jats:sup>+<\/jats:sup> T cells were increased compared with CD4<jats:sup>+<\/jats:sup> T\u2010cell population. Langerhans' cells were decreased. Proliferating stem cells, highlighted by Ki\u201067, showed a marked decrease in the bulge compared with uninvolved follicles.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Our study supports the finding that in LPP, the inflammatory infiltrate mainly involves the bulge region, where the stem cells reside. Once this area is damaged, the hair loses its potential of regrowth with resulting scarring alopecia. This is in contrast with inflammatory non\u2010scarring alopecias such as alopecia areata, where the bulb region is targeted, sparing the stem cells.<\/jats:p>","DOI":"10.1111\/j.0303-6987.2005.00399.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T15:00:32Z","timestamp":1161183632000},"page":"675-679","source":"Crossref","is-referenced-by-count":106,"title":["Possible role of the bulge region in the pathogenesis of inflammatory scarring alopecia: lichen planopilaris as the prototype"],"prefix":"10.1111","volume":"32","author":[{"given":"Narciss","family":"Mobini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideko","family":"Kamino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"285","volume-title":"Disorders of hair growth diagnosis and treatment","author":"Elston Maj DM","year":"1994"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1998.tb01476.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70290-V"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90696-C"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00050-7"},{"key":"e_1_2_5_7_2","volume-title":"Manual of histologic staining methods of the Armed Forces Institute of Pathology","author":"Luna LG","year":"1968"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-202X(93)90496-5"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00537.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70403-4"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00857.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/002203458106000311011"},{"key":"e_1_2_5_13_2","first-page":"411","article-title":"Parafollicular bulges, but not hair bulb keratinocytes are attacked in graft\u2010versus\u2010host disease of human skin","volume":"14","author":"Sale GE","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1997.tb01095.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03464.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1998.tb00312.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0303-6987.2005.00399.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0303-6987.2005.00399.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T16:35:41Z","timestamp":1697042141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0303-6987.2005.00399.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1111\/j.0303-6987.2005.00399.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0303-6987.2005.00399.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}