{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:49:35Z","timestamp":1787615375946,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,10]],"date-time":"2006-01-10T00:00:00Z","timestamp":1136851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Progressive mucinous histiocytosis is a rare, benign, non\u2010Langerhans' cell histiocytosis limited to the skin. Ten cases \u2013 all women \u2013 in four families and one sporadic case have been described in the literature. The disorder usually begins in childhood and progresses slowly. We report two sporadic cases of adult\u2010onset progressive mucinous histiocytosis in unrelated African\u2010American women, aged 48 and 55\u2003years, respectively, who developed red\u2010brown and flesh\u2010coloured, asymptomatic papules on the face, the arms and the legs without truncal, mucosal or visceral involvement. The lesions showed no spontaneous regression. Both patients lacked associated systemic symptoms, including polyuria, polydipsia or seizures. There was no underlying hyperlipidaemia, paraproteinaemia or lymphoproliferative disease. No family history of similar lesions could be identified. Light microscopy revealed dermal proliferation of spindle\u2010shaped histiocytes with abundant mucin deposition. Electron microscopy demonstrated a high number of myelin figures or zebra bodies in the cytoplasm of histiocytes. On immunohistochemistry, positive staining with macrophage markers \u2013 CD68, HAM56 and lysozyme \u2013 and factor XIIIa, a transglutaminase present in dermal dendrocytes, and negative staining with Langerhans' cell markers \u2013 CD1a and S100 \u2013 and CD34, a marker present in dermal dendritic cells derived from uncommitted mesenchymal cells, were observed.<\/jats:p>","DOI":"10.1111\/j.0303-6987.2006.00274.x","type":"journal-article","created":{"date-parts":[[2006,1,10]],"date-time":"2006-01-10T13:29:03Z","timestamp":1136899743000},"page":"166-170","source":"Crossref","is-referenced-by-count":16,"title":["Two sporadic cases of adult\u2010onset progressive mucinous histiocytosis"],"prefix":"10.1111","volume":"33","author":[{"given":"A.","family":"Young","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Olivere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1988.01670080037014"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690100084014"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90653-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03212.x"},{"key":"e_1_2_6_6_2","first-page":"400","article-title":"Hereditary progressive mucinous histiocytosis","volume":"127","author":"Antoni\u2010Bach N","year":"2000","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03255.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199606000-00008"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200305000-00003"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2340\/0001555574711","article-title":"Factor XIIIa expression in juvenile xanthogranuloma","volume":"74","author":"Misery L","year":"1994","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1986.01660230027002"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70001-7"},{"key":"e_1_2_6_13_2","first-page":"193","volume-title":"Skin pathology","author":"Strutton G","year":"2002"},{"key":"e_1_2_6_14_2","first-page":"1057","volume-title":"Skin pathology","author":"Weedon D","year":"2002"},{"key":"e_1_2_6_15_2","first-page":"917","volume-title":"Skin pathology","author":"Weedon D","year":"2002"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199009000-00008"},{"key":"e_1_2_6_17_2","first-page":"475","article-title":"Guess what! Multiple disseminated dermatofibromas in a woman with systemic lupus erythematosus","volume":"11","author":"Niiyama S","year":"2001","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000245985"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155502320323171"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03508.x"},{"key":"e_1_2_6_21_2","first-page":"1429","volume-title":"Dermatology","author":"Goodman WT","year":"2003"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2000.03723.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0303-6987.2006.00274.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0303-6987.2006.00274.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T23:36:56Z","timestamp":1696981016000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0303-6987.2006.00274.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,10]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1111\/j.0303-6987.2006.00274.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0303-6987.2006.00274.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,10]]}}}