{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:46:48Z","timestamp":1761630408949},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T00:00:00Z","timestamp":1145923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The most frequent molecular abnormality observed in dermatofibrosarcoma protuberans (DFSP) is the formation of a supernumerary ring chromosome or translocation resulting in fusion of the gene encoding the \u03b1\u2010chain of type 1 collagen, COL1A1 from 17q22, to the platelet\u2010derived growth factor \u03b2\u2010chain, PDGFB gene from 22q13. Rare cases documenting variant ring or marker chromosomes involving regions other than 17q22 and 22q13 have been reported. Further analysis in three of these cases demonstrated the presence of the COL1A1 and PDGFB genes.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We report a further case of DFSP with a rare variant ring chromosome. The tumor appeared to undergo accelerated growth during pregnancy, then metastasized following pregnancy. We describe the clinical, histological, immunohistochemical, and cytogenetic features.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The metastatic tumor showed a variant r(17;?) chromosome. A locus\u2010specific probe was required to demonstrate presence of the PDGFB gene within the ring, indicating cryptic molecular rearrangement between chromosomes 17 and 22, and recombination with an unknown chromosome.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Cryptic rearrangement of chromosomes 17 and 22 should be suspected in variant ring chromosomes and translocations. Pregnancy may contribute to accelerated growth of DFSP, and delay in surgical resection should be avoided.<\/jats:p>","DOI":"10.1111\/j.0303-6987.2006.00404.x","type":"journal-article","created":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T17:04:59Z","timestamp":1145984699000},"page":"383-388","source":"Crossref","is-referenced-by-count":20,"title":["Dermatofibrosarcoma protuberans: report of a case with a variant ring chromosome and metastases following pregnancy"],"prefix":"10.1111","volume":"33","author":[{"given":"Susan M.","family":"Bigby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Oei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil K.","family":"Lambie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pennie 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