{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T15:26:42Z","timestamp":1782055602599,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,6,6]],"date-time":"2006-06-06T00:00:00Z","timestamp":1149552000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Histiocytic sarcoma is an exceedingly rare malignant neoplasm composed of cells with a monocyte\/macrophage phenotype. In the current nosology of histiocytic neoplasms, histiocytic sarcoma is separate from indeterminate cell histiocytosis, a generally benign disorder characterized by proliferation of a CD1a<jats:sup>+<\/jats:sup> and S\u2010100<jats:sup>+<\/jats:sup> population of cells lacking Birbeck granules usually limited to the skin.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We present a case of histiocytic sarcoma in a 64\u2010year\u2010old man presenting as a peritonsillar mass and secondarily involving the skin.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The malignant cells in the extracutaneous foci of disease expressed macrophage\u2010associated antigens including S\u2010100 but were CD1a<jats:sup>\u2013<\/jats:sup>. The malignant cells in the skin coexpressed CD1a and S\u2010100 but lacked ultrastructural features of Langerhans cells, findings indicative of indeterminate cells.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> We discuss the clinical and histopathologic differential diagnosis in association with prior reported cases of histiocytic sarcoma, particularly in cases involving the skin and cases expressing the Langerhans cell\u2010associated antigen CD1a.<\/jats:p>","DOI":"10.1111\/j.0303-6987.2006.00453.x","type":"journal-article","created":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T09:48:15Z","timestamp":1149673695000},"page":"437-442","source":"Crossref","is-referenced-by-count":16,"title":["Histiocytic sarcoma with secondary involvement of the skin and expression of CD1a: evidence of indeterminate cell differentiation?"],"prefix":"10.1111","volume":"33","author":[{"given":"John L.","family":"Frater","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Kling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Obadiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard E.","family":"Grosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Resh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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