{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:44:58Z","timestamp":1759333498993},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T00:00:00Z","timestamp":1143590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> t(14;18)(q32;q21) involving <jats:italic>IGH<\/jats:italic> and <jats:italic>MALT1<\/jats:italic> has been demonstrated in cutaneous MALT lymphomas and in one case of primary cutaneous diffuse large B\u2010cell lymphoma (DLBCL). However, the incidence of <jats:italic>IGH<\/jats:italic>\/<jats:italic>MALT1<\/jats:italic> translocations in these forms of cutaneous lymphoma remains unclear.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We performed paraffin section interphase fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH) analysis using <jats:italic>MALT1<\/jats:italic> and <jats:italic>IGH<\/jats:italic> break\u2010apart probes on 16 cutaneous MALT lymphomas and 16 primary cutaneous DLBCL in order to assess the frequency of <jats:italic>IGH<\/jats:italic>\/<jats:italic>MALT1<\/jats:italic> translocations and to screen for other potential translocations involving the <jats:italic>IGH<\/jats:italic> or <jats:italic>MALT1<\/jats:italic> loci.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Translocations involving <jats:italic>MALT1<\/jats:italic> were not detected in any of 16 cutaneous MALT lymphomas or 16 primary cutaneous DLBCL. Of the 12 MALT lymphomas that could be analyzed for an <jats:italic>IGH<\/jats:italic> translocation, all were negative. In contrast, four of the 13 cases (31%) of primary cutaneous DLBCL that could be analyzed for translocations involving <jats:italic>IGH<\/jats:italic> were positive. Subsequent FISH analysis demonstrated one of these to be an <jats:italic>IGH<\/jats:italic>\/<jats:italic>BCL2<\/jats:italic> translocation and one to be a <jats:italic>CMYC<\/jats:italic>\/<jats:italic>IGH<\/jats:italic> translocation, while the translocation partners in the remaining two cases are currently unidentified.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> This study demonstrates that translocations involving <jats:italic>MALT1<\/jats:italic>, including <jats:italic>IGH<\/jats:italic>\/<jats:italic>MALT1<\/jats:italic>, are uncommon in cutaneous MALT lymphomas and primary cutaneous DLBCL. Other translocations involving <jats:italic>IGH<\/jats:italic> also are not involved in the pathogenesis of at least most cutaneous MALT lymphomas. In contrast, primary cutaneous DLBCL may contain one of several <jats:italic>IGH<\/jats:italic> translocations in a minority of cases.<\/jats:p>","DOI":"10.1111\/j.0303-6987.2006.00459.x","type":"journal-article","created":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T13:35:50Z","timestamp":1143639350000},"page":"286-292","source":"Crossref","is-referenced-by-count":26,"title":["t(14;18)(q32;q21) involving <i>IGH<\/i> and <i>MALT1<\/i> is uncommon in cutaneous MALT lymphomas and primary cutaneous diffuse large B\u2010cell lymphomas"],"prefix":"10.1111","volume":"33","author":[{"given":"Nicholas T.","family":"Wongchaowart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric D.","family":"Hsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven 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