{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:07:05Z","timestamp":1770822425562,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,6,6]],"date-time":"2006-06-06T00:00:00Z","timestamp":1149552000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Subcutaneous T\u2010cell lymphoma (STCL) represents a controversial entity and a confused concept in the field of cutaneous T\u2010cell lymphomas (CTCLs). Recently, \u03b1\/\u03b2<jats:sup>+<\/jats:sup>\/CD8<jats:sup>+<\/jats:sup> STCL has been recognized by the new World Health Organization (WHO)\u2013European Organization for Research and Treatment of Cancer (EORTC) classification of primary cutaneous lymphomas as a distinct entity in the group of CTCLs.<\/jats:p><jats:p><jats:bold>Observations:\u2002<\/jats:bold> We reviewed a series of 53 biopsies from 26 patients (F\u2003:\u2003M\u2003=\u200319:7; median age: 48; range 18\u201387) of cutaneous B\u2010 and T\u2010cell lymphomas characterized by prominent involvement of the subcutaneous tissue. We could classify our cases according to the following seven categories \u2013 (i) STCL: n\u2003=\u200316; (ii) extranodal NK\/T\u2010cell lymphoma, nasal type: n\u2003=\u20032; (iii) cutaneous \u03b3\/\u03b4 T\u2010cell lymphoma: n\u2003=\u20032; (iv) anaplastic CD30<jats:sup>+<\/jats:sup> large T\u2010cell lymphoma: n\u2003=\u20031; (v) diffuse large B\u2010cell lymphoma, secondary cutaneous: n\u2003=\u20033; (vi) lymphoplasmacytic lymphoma, secondary cutaneous: n\u2003=\u20031; (vii) specific cutaneous manifestations of myelogenous leukemia: n\u2003=\u20031.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> We demonstrated the protean nature of lymphomas with prominent involvement of the subcutaneous fat tissues. The term STCL should be restricted to a homogeneous group of cases characterized morphologically by an exclusive involvement of subcutaneous tissues, immunohistochemically by a T\u2010cytotoxic \u03b1\/\u03b2 phenotype, and biologically by a relatively good prognosis.<\/jats:p>","DOI":"10.1111\/j.0303-6987.2006.00493.x","type":"journal-article","created":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T05:48:15Z","timestamp":1149659295000},"page":"418-425","source":"Crossref","is-referenced-by-count":47,"title":["The protean spectrum of non\u2010Hodgkin lymphomas with prominent involvement of subcutaneous fat"],"prefix":"10.1111","volume":"33","author":[{"given":"Cesare","family":"Massone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Piero","family":"Lozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friederike","family":"Egberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Fink\u2010Puches","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Cota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Kerl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Cerroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199101000-00002"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470987445"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20502"},{"key":"e_1_2_5_5_2","first-page":"212","volume-title":"World Health Organization Classification of Tumours. 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