{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:06:59Z","timestamp":1764173219909},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,7,29]],"date-time":"2004-07-29T00:00:00Z","timestamp":1091059200000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold>  <jats:bold>Malignant melanoma of the vulva in childhood is a rare neoplasm. Lichen sclerosus of the vulva in childhood is also a rare disease. The association of these two rare lesions in the vulva of young girls is extremely rare. We present a 10\u2010year\u2010old white girl with malignant melanoma associated with lichen sclerosus of the vulva. She had dark pigmentation of both the labia minora and posterior fourchette. The inner labia majora and fourchette showed whitish, glistening areas of skin. Histologic examination found mostly an in situ lentiginous\/mucosal melanoma with focal invasion to a depth of 0.44 mm in the left upper labium majus. All specimens showed evidence of lichen sclerosus. Partial vulvectomy was performed, and no metastases were detected at the time of treatment. The patient has been disease free for the 12 months after treatment. It is critical for physicians to realize that melanoma can occur in children, and although rare, can occur in the vulva. We feel that lichen sclerosus in this instance may represent a pattern of host immune response to melanoma.<\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.0736-8046.2004.21412.x","type":"journal-article","created":{"date-parts":[[2004,7,30]],"date-time":"2004-07-30T05:15:35Z","timestamp":1091164535000},"page":"473-476","source":"Crossref","is-referenced-by-count":43,"title":["Malignant Melanoma Associated with Lichen Sclerosus in the Vulva of a 10\u2010Year\u2010Old"],"prefix":"10.1111","volume":"21","author":[{"given":"Ashraf M.","family":"Hassanein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan E.","family":"Mrstik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy S.","family":"Hardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda A.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,29]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890390083011"},{"key":"e_1_2_4_3_2","first-page":"206","article-title":"Cutaneous melanoma","volume":"4","author":"Hoffman SJ","year":"1998","journal-title":"Cancer J Sci Am"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70562-1"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981015)83:8<1664::AID-CNCR23>3.0.CO;2-G"},{"key":"e_1_2_4_6_2","first-page":"253","article-title":"Malignant melanoma in association with lichen sclerosus on the vulva of a 14\u2010year\u2010old","volume":"6","author":"Friedman RJ","year":"1984","journal-title":"Am J Dermatopathol"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113474"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503093321007"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991001)86:7<1273::AID-CNCR24>3.0.CO;2-Z"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2001.00087.x"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1988.tb01748.x"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90060-8"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200110000-00005"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64924-3"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00022744-200106000-00008"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200204000-00001"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.1.77"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8545(00)80005-4"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200204000-00005"},{"issue":"3","key":"e_1_2_4_20_2","first-page":"61S","article-title":"Merkel cell carcinoma of the vulva","volume":"63","author":"Bottles K","year":"1984","journal-title":"Obstet Gynecol"},{"issue":"11","key":"e_1_2_4_21_2","first-page":"16","article-title":"Basal cell carcinoma of the vulva in association with vulval lichen sclerosus et atrophicus","volume":"78","author":"Thomas RH","year":"1985","journal-title":"J R Soc Med"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.0736-8046.2004.21412.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.0736-8046.2004.21412.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T19:58:03Z","timestamp":1697140683000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.0736-8046.2004.21412.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1111\/j.0736-8046.2004.21412.x"],"URL":"https:\/\/doi.org\/10.1111\/j.0736-8046.2004.21412.x","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}